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The Development and Application of a Monoclonal Antibody Purification Platform
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Judy Glynn
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Timothy Hagerty
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Timothy Pabst, PhD
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Gopinath Annathur
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Kristin Thomas
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Paul Johnson
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Natarajan Ramasubramanyan, PhD
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Paul Mensah, PhD
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A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies.
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Virus Clearance Strategy Using a Three-Tier Orthogonal Technology Platform
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| By
Suma Ray, PhD
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Klaus Tarrach
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How to implement a risk-based approach to eliminate viruses using orthogonal technologies.
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Hydrophobic Membrane Adsorbers for Large-Scale Downstream Processing
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| By
Nathalie Frau, PhD
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Michael Kuczewski
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Gregory Zarbis-Papastoitsis, PhD
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Miyako Hirai
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This alternative to column chromatography is suitable for flow-through as well as bind-and-elute purification operations.
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Salt Tolerant Interaction Chromatography for Large-Scale Polishing with Convective Media
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| By
Rene Faber, PhD
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Yujing Yang, PhD
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Uwe Gottschalk, PhD
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STIC allows polishing to be carried out without an interstitial dilution step, which reduces process time and avoids additional buffer preparation and hold steps.
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A Purification Platform for the Production of MAbs from Fermenters with Titers of 5 g/L and Beyond
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| By
Jim Davies
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New techniques can overcome bottlenecks in existing facilities.
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Economic Drivers and Trade-Offs in Antibody Purification Processes
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| By
Suzanne S. Farid, PhD
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The future of therapeutic MAbs lies in the development of economically feasible downstream processes.
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Antibody Purification Using Membrane Adsorbers
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| By
Leonardo Giovannoni, PhD
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Marco Ventani
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Uwe Gottschalk, PhD
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A membrane adsorber in retention mode can be used efficiently in a commercial antibody manufacturing process.
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Precipitation of Process-Derived Impurities in Non-Protein A Purification Schemes for Antibodies
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Jue (Michelle) Wang, PhD
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Timothy Diehl
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Deena Aguiar
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Xiao-Ping Dai, PhD
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Alahari Arunakumari, PhD
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Precipitation prior to capture chromatography offers a simple, robust, and economical method to remove CHO host cell proteins and DNA.
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