BioPharm International Supplements, October 2009 - BioPharm International

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BioPharm International Supplements, October 2009
Peer-Reviewed Research
Hydrophobic Membrane Adsorbers for Large-Scale Downstream Processing
By Nathalie Frau, PhD , Michael Kuczewski , Gregory Zarbis-Papastoitsis, PhD , Miyako Hirai
This alternative to column chromatography is suitable for flow-through as well as bind-and-elute purification operations.
A Purification Platform for the Production of MAbs from Fermenters with Titers of 5 g/L and Beyond
By Jim Davies
New techniques can overcome bottlenecks in existing facilities.
Economic Drivers and Trade-Offs in Antibody Purification Processes
By Suzanne S. Farid, PhD
The future of therapeutic MAbs lies in the development of economically feasible downstream processes.
Precipitation of Process-Derived Impurities in Non-Protein A Purification Schemes for Antibodies
By Jue (Michelle) Wang, PhD , Timothy Diehl , Deena Aguiar , Xiao-Ping Dai, PhD , Alahari Arunakumari, PhD
Precipitation prior to capture chromatography offers a simple, robust, and economical method to remove CHO host cell proteins and DNA.
Antibody Purification Using Membrane Adsorbers
By Leonardo Giovannoni, PhD , Marco Ventani , Uwe Gottschalk, PhD
A membrane adsorber in retention mode can be used efficiently in a commercial antibody manufacturing process.
Salt Tolerant Interaction Chromatography for Large-Scale Polishing with Convective Media
By Rene Faber, PhD , Yujing Yang, PhD , Uwe Gottschalk, PhD
STIC allows polishing to be carried out without an interstitial dilution step, which reduces process time and avoids additional buffer preparation and hold steps.
Virus Clearance Strategy Using a Three-Tier Orthogonal Technology Platform
By Suma Ray, PhD , Klaus Tarrach
How to implement a risk-based approach to eliminate viruses using orthogonal technologies.
The Development and Application of a Monoclonal Antibody Purification Platform
By Judy Glynn , Timothy Hagerty , Timothy Pabst, PhD , Gopinath Annathur , Kristin Thomas , Paul Johnson , Natarajan Ramasubramanyan, PhD , Paul Mensah, PhD
A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies.

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