BioPharm International Supplements, March 2009 - BioPharm International

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BioPharm International Supplements, March 2009
Articles
A Purification Platform for the Production of MAbs from Fermenters with Titers of 5 g/L and Beyond
By Jim Davies
New techniques can greatly improve the MAb purification process.
Purification Strategies to Process 5 g/L Titers of Monoclonal Antibodies
By Melody Trexler-Schmidt , Stefanie Sze-Khoo , Amber R. Cothran , Binh Q. Thai , Sandy Sargis , Benedicte Lebreton , Brian Kelley , Gregory S. Blank
Altering the order of operations, using new resins, and increasing dynamic binding capacity can obviate the need for major facilty changes.
Advances in Non-Protein A Purification Processes for Human Monoclonal Antibodies
By Alahari Arunakumari, PhD , Jue (Michelle) Wang, PhD , Gisela Ferreira, PhD
In three non-affinity purification processes based on cation exchange capture with high binding capacity, applying a host cell protein exclusion strategy enabled robust scale up and better economics.
The Development and Application of a Monoclonal Antibody Purification Platform
By Judy Glynn , Timothy Hagerty , Timothy Pabst, PhD , Gopinath Annathur , Kristin Thomas , Paul Johnson , Natarajan Ramasubramanyan, PhD , Paul Mensah, PhD
A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies.
Platform Technology for Developing Purification Processes
By Michel H.M. Eppink , Rick Schreurs , Anke Gijsen , Kees Verhoeven
The future of therapeutic MAbs lies in the development of economically feasible downstream processes.
Economic Drivers and Trade-Offs in Antibody Purification Processes
By Suzanne S. Farid, PhD
The future of therapeutic MAbs lies in the development of economically feasible downstream processes.
Advertisers in This Issue
Millipore
Sartorius Stedim Biotech SA
Asahi Kasei
Tosoh
Pall Corporation
GE Healthcare
Bio-Rad Laboratories
Azopharma Inc.

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