BioPharm International Supplements, March 2008 - BioPharm International

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BioPharm International Supplements, March 2008
Articles
Optimizing the Primary Recovery Step in Nonaffinity Purification Schemes for HuMAbs
By Jue (Michelle) Wang, PhD , Timothy Diehl , Mark Watkins-Fischl , Deborah Perkins , Deena Aguiar , Alahari Arunakumari, PhD
An alternative approach to traditional Protein A schemes is comparable in overall efficiency, product recovery, and quality.
Purification of IgM Monoclonal Antibodies
By Pete Gagnon , Frank Hensel , Richard Richieri
Manufacturing challenges surround the use of IgM monoclonal antibodies, but these can be overcome with current technology.
Solutions for Purification of Fc-fusion Proteins
By Douglas W. Rea , Michiel E. Ultee, PhD , Sharon X. Chen , Thomas P. Loisel
When platform processes are applied to fusion molecules, innovation and flexibility are needed.
Economic Drivers and Trade-Offs in Antibody Purification Processes
By Suzanne S. Farid, PhD
The future of therapeutic MAbs lies in the development of economically feasible downstream processes.
Process-Scale Precipitation of Impurities in Mammalian Cell Culture Broth
By Judy Glynn
If certain engineering challenges can be addressed, precipitation may prove to be a valuable tool for antibody purification.

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