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Design and Testing of a Prototype Large-Scale Bag Freeze–Thaw System
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Philippe Lam
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Samir Sane
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A solution for the problems of a "bag in a can" system would be a fully jacketed and insulated container, similar to a traditional freeze tank.
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A Next Step in Implementing Disposables: Transfer Lines
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John Boehm
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Single-use systems reduce maintenance and capital expense by eliminating expensive vessels, valves, and sanitary piping assemblies.
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Antibody Purification with an Integrated Disposable Assembly
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Gazala Khan-Koticha
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Lisa Nakakihara
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Lee Tucker
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John Scarcella
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Eric Rudolph
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Comparison of the integrated assembly purified MGG to the control revealed that the purity if the MGG was very high.
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Disposable Process for cGMP Manufacture of Plasmid DNA
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Paul Lloyd-Evans
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Denise A. Phillips
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Antony C.C. Wright
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R. Keith Williams
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Disposables are increasingly being used in the manufacture of biopharmaceuticals. This article describes the design of a fully disposable process for the cGMP manufacture of clinical trial grade plasmid DNA. It addresses the rationale for implementing such a process with respect to the manufacture of patient-specific plasmid DNA vaccines for the treatment of leukemia. The process incorporates a number of disposable technologies, which are simple to use and thus reduce the need for investment in expensive equipment and cleaning validation.
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Single-Use Technologies—A Contract Biomanufacturer's Perspective
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Imara Charles
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Janet Lee
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Yamuna Dasarathy
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One of the challenges of adopting single-use technology is that not all cell lines are compatible with disposable bioreactors.
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