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The Evolution of Protein Expression and Cell Culture
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Antonio R. Moreira
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It is commonly believed that technologies in the next 10–15 years will enable sequencing an individualized human genome for less than $1,000. With innovations like these, the twenty-first century will certainly belong to biotechnology. From an industrial standpoint, the discovery of therapeutic molecules and the development of cell lines and processes to produce these molecules will be of paramount importance. This article describes various approaches that have been prevalent in the industry or are likely to be used in the future for generating cell lines with desirable traits and developing high titer cell culture processes.
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Process Chromatography: Five Decades of Innovation
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John Curling
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Uwe Gottschalk, PhD
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Low-pressure process chromatography could not have developed without immense efforts to resolve scale-up issues in both column design and matrix stability.
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The Changing Landscape of Global Vaccine Development and Market Potential
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Hank Liu
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It is hoped that HIV patients' own immune responses can be strengthened by vaccines so they will not have to rely exclusively on antiretroviral drugs.
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Glycosylation and the Demands of Antibody Engineering
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K. John Morrow, Jr., PhD
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In one series of experiments, the glycosylation site of IgG1 was removed and an IgA glycosylation site was introduced—resulting in a total loss of biological function.
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Applications of MVDA in Biotech Processing
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Anurag S. Rathore, PhD
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Rob Johnson
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Oliver Yu
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Alime Ozlem Kirdar
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Alagappan Annamalai
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Sanjeev Ahuja
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Kripa Ram
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Multivariate data analysis can help biotech manufacturers deepen their process understanding.
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Protein Therapeutics and the Regulation of Quality: A Brief History
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Steven Kozlowski
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Regulatory agencies have evolved along with the biotechnology industry to define quality standards.
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On the Biotechnology Frontier: Personalized Medicine, A Discussion with E.J. Brandreth
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Favrille, a San Diego-based biopharmaceutical company, is one of a handful of firms on the forefront of personalized medicine. Because personalized treatment is tailored to an individual's biology, it has the potential to be far more effective than current approaches to disease management.
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Biotechnology: Past, Present, and Future
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G. Steven Burrill
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Thirty years after the first biotechnology company opened, the sector is reaching a new level of maturity and globalization.
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Biotech Manufacturing Grows Up
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Michael E. Kamarck
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Louane E. Hann
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S. Robert Adamson
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It became a strategic imperative to find a better, more efficient way to manufacture our products. To continue with the status quo was untenable.
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