http://www.biopharminternational.com/biopharm/Downstream+Processing/Article/list/39223 The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here. 2013-05-23T18:00:48Z http://www.biopharminternational.com/biopharm/Feature+Rotating+Article/Aggregation-of-Monoclonal-Antibody-Products-Format/ArticleStandard/Article/detail/809074?contextCategoryId=39223&ref=25 Aggregate formation is influenced by multiple aspects of the bioproduction process but can be mitigated by good process design and control. 2013-03-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142013/809074/Rathore-Figure-1_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Polishing-Complex-Therapeutic-Proteins/ArticleStandard/Article/detail/802139?contextCategoryId=39223&ref=25 A new downstream purification platform using a salt-tolerant membrane adsorber. 2013-01-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/022013/802139/PeerReviewbutton_main.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/022013/802139/BP0113_135018895_High_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/The-Future-of-Biopharma/ArticleStandard/Article/detail/802143?contextCategoryId=39223&ref=25 What the industry's future holds and what needs to be done to get there. 2013-01-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/022013/802143/BP0113_bp0113_136120148-1_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/A-New-Scale-Down-Membrane-Adsorber-Device-for-Proc/ArticleStandard/Article/detail/798942?contextCategoryId=39223&ref=25 The authors describe the development of an ultra scale-down anion exchange membrane adsorber, and demonstrate scalability to larger-scale devices. 2012-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492012/798942/PeerReviewbutton_main.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492012/798942/Fraud-Figure-2_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Closures-for-Pharmaceutical-Preparations-A-Review-/ArticleStandard/Article/detail/798941?contextCategoryId=39223&ref=25 The author examines the use of closures for products intended for injection. 2012-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492012/798941/PeerReviewbutton_main.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492012/798941/77894262_cmyk_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Quality/The-Challenges-of-Adopting-Single-Use-Technology/ArticleStandard/Article/detail/796136?contextCategoryId=39223&ref=25 Insights on single-use systems implementation and exploitation in biopharmaceutical manufacturing and processing, based on a QbD approach. 2012-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796136null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Upstream-Downstream-Processing-in-Motion/ArticleStandard/Article/detail/796141?contextCategoryId=39223&ref=25 GE Healthcare Life Sciences' ReadyToProcess platform aims to streamline bioprocessing. 2012-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796141/GEHealthcareRTR_Interior_Web_flash.jpg XML http://www.biopharminternational.com/biopharm/Disposables+Advisor/Its-an-Election-Year-Are-You-Making-the-Best-Choic/ArticleStandard/Article/detail/796143?contextCategoryId=39223&ref=25 The author considers the types of tubing available to the industry and how to make an informed selection. 2012-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796143null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/A-25-Year-Retrospective-on-Protein-Recovery-throug/ArticleStandard/Article/detail/796157?contextCategoryId=39223&ref=25 This month, Jerold Martin of Pall Life Sciences takes a look at protein recovery through direct-flow microporous membrane filters over the past 25 years. 2012-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796157null XML http://www.biopharminternational.com/biopharm/Quality/EU-Sets-Guidelines-for-Biosimilar-mAbs/ArticleStandard/Article/detail/796152?contextCategoryId=39223&ref=25 The European Medicines Agency has added granularity to its biosimilars approval pathway by releasing a guideline on mAbs. 2012-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796152/dv321052_3_cmyk_Web_flash.jpg XML http://www.biopharminternational.com/biopharm/Basic+Training/Downstream-Processing-A-Primer/ArticleStandard/Article/detail/791271?contextCategoryId=39223&ref=25 NIBRT's Ian Nelligan on what to expect when starting a downstream process. 2012-10-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/402012/791271null XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/In-Depth-Validation-of-Closed-Vial-Technology/ArticleStandard/Article/detail/787745?contextCategoryId=39223&ref=25 The authors describe a validation master plan for closed-vial filling technology. 2012-09-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/362012/787745/BP0912_34_Verjans-Figure-1_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/A-25-Year-Retrospective-on-Bioprocessing-mAbs/ArticleStandard/Article/detail/787749?contextCategoryId=39223&ref=25 Michiel E. Ultee of Laureate Biopharmaceutical Services gives an update on 1988 article regarding virus testing and how the advance of monoclonal antibodies has changed processes. 2012-09-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/362012/787749null XML http://www.biopharminternational.com/biopharm/Feature+Rotating+Article/A-25-Year-Retrospective-on-Bio-Engineering/ArticleStandard/Article/detail/781175?contextCategoryId=39223&ref=25 Steven S. Kuwahara, PhD, principal consultant at GXP BioTechnology LLC, gives an update on "Engineering the Cell-System Interface." 2012-07-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/282012/781175null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Biomanufacturing-Innovation/ArticleStandard/Article/detail/781182?contextCategoryId=39223&ref=25 Industry wants more innovation, but can suppliers meet customers' needs? 2012-07-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/282012/781182null XML http://www.biopharminternational.com/biopharm/Quality/25-Years-of-BioPharma-Industry-Growth/ArticleStandard/Article/detail/775160?contextCategoryId=39223&ref=25 A review of key industry shifts and promises for the future. 2012-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/212012/775160/BP0612_21_140654677-2-Duotone_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/25-Years-of-Nanoparticles-A-Look-Forward/ArticleStandard/Article/detail/775165?contextCategoryId=39223&ref=25 Panayiotis P. Constantinides of Biopharmaceutical & Drug Delivery Consulting on growth of nanoparticle delivery systems. 2012-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/212012/775165null XML http://www.biopharminternational.com/biopharm/Quality/25-Years-of-Biopharmaceutical-Innovation-An-Expert/ArticleStandard/Article/detail/775157?contextCategoryId=39223&ref=25 Industry experts discuss significant achievements. Plus: What's in store for the future. 2012-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/212012/775157/BP0612_54_Covers-1988_Jan_flash.jpg XML http://www.biopharminternational.com/biopharm/Feature+Rotating+Article/Development-of-an-Alternative-Monoclonal-Antibody-/ArticleStandard/Article/detail/771924?contextCategoryId=39223&ref=25 MAb polishing using salt tolerant interaction membrane chromatography. 2012-05-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182012/771924/BP0512_38_Kang-Figure-1a_flash.jpg XML http://www.biopharminternational.com/biopharm/Feature+Rotating+Article/Optimizing-Drug-Delivery-for-Modern-Biologics/ArticleStandard/Article/detail/771928?contextCategoryId=39223&ref=25 This article discusses potential opportunities to improve the patient experience through formulation and delivery device technologies. 2012-05-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182012/771928null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Single-Use-Redundant-Filtration/ArticleStandard/Article/detail/767896?contextCategoryId=39223&ref=25 The authors describe a new assembly for bulk and final drug product filling operations. 2012-04-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142012/767896/BP0412_113477336_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Pointed-Debate/ArticleStandard/Article/detail/767891?contextCategoryId=39223&ref=25 Industry experts discuss the benefits and challenges of self-administration of injectable therapies. 2012-04-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142012/767891/BP0412_82047762_Cvr-St_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Optimizing-Adjuvant-Filtration/ArticleStandard/Article/detail/767889?contextCategoryId=39223&ref=25 A technical rountable featuring Sartorius Stedim Biotech, Pall Life Sciences, 3M Purification, Asahi Kasei Bioprocess, and Bio-Rad Laboratories. 2012-04-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142012/767889/BP0412_Sartorius_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Recombinant-Albumin-Facilitates-Formulation-Design/ArticleStandard/Article/detail/763570?contextCategoryId=39223&ref=25 Recombinant albumin can stabilize a drug product and assist in API release. 2012-03-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/102012/763570/BP0312_41_Sharpe_Figure-1_flash.jpg XML http://www.biopharminternational.com/biopharm/Quality%2FGMP%2FValidation++Whitepapers/Assessing-Filling-Technologies-For-Contamination-R/ArticleStandard/Article/detail/763575?contextCategoryId=39223&ref=25 The authors compare the exposure risk from viable particles from the air supply in four well-established aseptic filling technologies. 2012-03-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/102012/763575null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Ice-Fog-as-a-Means-to-Induce-Uniform-Ice-Nucleatio/ArticleStandard/Article/detail/754430?contextCategoryId=39223&ref=25 The authors describe a novel means to control ice nucleation using a sterile cryogenic ice fog. 2012-01-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/532011/754430/PeerReviewbutton_main.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/532011/754430/BP0112_37_Chakravartya-Figure-5_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Quality/A-25-Year-Retrospective-on-Separations-Technology/ArticleStandard/Article/detail/754428?contextCategoryId=39223&ref=25 This month, we rewind to "Separations Technology Outlook, Part II: Improved Recovery and Greater Purity." 2012-01-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/532011/754428null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Therapeutic-Vaccine-Outlook/ArticleStandard/Article/detail/754816?contextCategoryId=39223&ref=25 Has an approval in oncology reignited interest in the recruitment of the immune system in the fight against disease? 2012-01-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/012012/754816/BP0112_25_95468876_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/An-Overview-of-Risk-Assessment-Strategies-for-Extr/ArticleStandard/Article/detail/754432?contextCategoryId=39223&ref=25 Approaches for risk assessment of extractables and leachables. 2012-01-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/532011/754432/BP0112_41_Tutorial-Stone_Figure-1_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Efficient-Prion-Removal-from-Gonadotropin-Solution/ArticleStandard/Article/detail/750861?contextCategoryId=39223&ref=25 Can a nanofiltration process be leveraged for removal of prions? 2011-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492011/750861/BP1211_37_Prion_Figure1_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Quality%2FGMP%2FValidation++Whitepapers/The-Employment-Outlook-Brightens/ArticleStandard/Article/detail/750859?contextCategoryId=39223&ref=25 Readers react to the economic turmoil of the past year and look longingly forward to 2012. 2011-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492011/750859/BP1211_22_103772148_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Disposables/Approaches-for-Flexible-Manufacturing-Facilities-i/ArticleStandard/Article/detail/746266?contextCategoryId=39223&ref=25 With careful analysis to mitigate risk, disposable technology and process closure can enable adaptable designs and reduced costs. 2011-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442011/746266null XML http://www.biopharminternational.com/biopharm/Quality/DNA-Vaccine-Delivery/ArticleStandard/Article/detail/742599?contextCategoryId=39223&ref=25 Development of the ideal DNA vaccine requires the optimization of delivery strategies and plasmid vectors. 2011-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/412011/742599/BPsupp1011_Cobra-ORT-VAC-New-Figure-2_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Quality/Challenges-and-Trends-in-Vaccine-Manufacturing/ArticleStandard/Article/detail/742600?contextCategoryId=39223&ref=25 An evaluation of the technologies needed to develop a safe, effective, and economically efficient vaccine. This article is part of a special section on vaccines. 2011-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/412011/742600/BPsupp1011_Cv1_v3r2_high_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Quality/Contract-Services-Spending-Whos-Spending-What-and-/ArticleStandard/Article/detail/742603?contextCategoryId=39223&ref=25 A survey provides insight into drug companies' plans for spending on outsourced services. This article contains bonus online material. 2011-10-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/412011/742603null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/The-Future-of-Downstream-Processing/ArticleStandard/Article/detail/737338?contextCategoryId=39223&ref=25 The author reviews the state of downstream processing, including a look at the streamlining of full processes and borrowed technologies. 2011-09-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/352011/737338/BP0911_Open-Art---Sartorius_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Operations/Organizational-Structures-of-Process-Development-a/ArticleStandard/Article/detail/737331?contextCategoryId=39223&ref=25 How to strike a balance between site autonomy and global coordination. 2011-09-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/352011/737331/PeerRevButton_main.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/352011/737331/BP0911_Konstantinov-Figure-2_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Technologies-for-Downstream-Processing/ArticleStandard/Article/detail/737333?contextCategoryId=39223&ref=25 The author describes recent developments to help overcome the downstream-processing bottleneck. 2011-09-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/352011/737333/BP0911_001_Cover_thumbnail_web_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Analysis-of-PEGylated-Protein-by-Tetra-Detection-S/ArticleStandard/Article/detail/733325?contextCategoryId=39223&ref=25 Reliably detecting low amounts of high molecular weight impurities during process development and characterization of biopharmaceutical products. 2011-08-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/312011/733325null XML http://www.biopharminternational.com/biopharm/Quality/Top-1000-Global-Biomanufacturing-Facilities/ArticleStandard/Article/detail/733328?contextCategoryId=39223&ref=25 Insights from real-time ranking of global biomanufacturing capabilities. 2011-08-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/312011/733328/Top1000webNew_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Nontuberculosis-Mycobacterium-Contamination-of-a-M/ArticleStandard/Article/detail/724372?contextCategoryId=39223&ref=25 The authors present a case study identifying a contaminant. 2011-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/222011/724372/PeerRevButton_main.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/222011/724372/BP0611_Nims_Figure-1_Web_flash.jpg XML http://www.biopharminternational.com/biopharm/Quality/Outsourcing-Lean-Quality-Manufacturing/ArticleStandard/Article/detail/718075?contextCategoryId=39223&ref=25 Rapid microbial screening provided by contract laboratories can save companies time and money. 2011-05-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182011/718075/bp0511_Celsis.web_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Considerations-in-Identification-and-Qualification/ArticleStandard/Article/detail/718076?contextCategoryId=39223&ref=25 The authors outline qualification procedures for a process-critical piece of equipment. 2011-05-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182011/718076/PeerReviewbutton_main.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182011/718076null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Addressing-the-Challenges-in-Downstream-Processing/ArticleStandard/Article/detail/714708?contextCategoryId=39223&ref=25 Newer classes of biotherapies will require innovations in processing technology. 2011-04-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142011/714708null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Innovation-and-the-Art-of-Downstream-Processing/ArticleStandard/Article/detail/714709?contextCategoryId=39223&ref=25 This summary provides an introduction to our special issue on Separation and Purification. 2011-04-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142011/714709/BPsupp0411_Uwewebr_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Meningitis-Vaccine-Manufacturing-Fermentation-Harv/ArticleStandard/Article/detail/714707?contextCategoryId=39223&ref=25 Careful analysis of an unusual precipitate identifies defects. 2011-04-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142011/714707/BPsupp0411_Leewebr_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Benefits-of-a-Revised-Approach-to-Anion-Exchange-F/ArticleStandard/Article/detail/714706?contextCategoryId=39223&ref=25 A high-performance anion exchange resin performs well compared with membranes. In addition, the resin offers greater flexibility and cost savings. 2011-04-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142011/714706null XML http://www.biopharminternational.com/biopharm/Quality/New-Binary-Gas-Integrity-Test-Improves-Membrane-Qu/ArticleStandard/Article/detail/714715?contextCategoryId=39223&ref=25 The authors developed a test for defects in filter membranes. 2011-04-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142011/714715/PeerReviewbutton_main.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142011/714715/BP0411_Krishnanwebr_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Systematic-Approaches-to-Develop-Chemically-Define/ArticleStandard/Article/detail/695161?contextCategoryId=39223&ref=25 Making chemically defined media work. 2010-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462010/695161/BP1110_Pacis_flash.jpeg XML http://www.biopharminternational.com/biopharm/Multimedia/Podcast-Answers-to-Your-Questions-about-QbD/ArticleStandard/Article/detail/690731?contextCategoryId=39223&ref=25 Hundreds of listeners tuned into our recent web seminar on Quality by Design, and we didn?t have time to answer all their questions. Fortunately, our speakers gathered to answer the common questions in this podcast. 2010-10-11T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422010/690731null HTML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/Characterization-of-Aluminum-Hydroxide-Gel-and-Oil/ArticleStandard/Article/detail/690800?contextCategoryId=39223&ref=25 Adjuvant activity can be greatly improved by appropriate formulation of cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs). 2010-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422010/690800null XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/Release-and-Stability-Testing-Programs-for-a-Novel/ArticleStandard/Article/detail/690799?contextCategoryId=39223&ref=25 Release testing involves both standard potency assays and unique assays (particle size, NA activity) developed to ensure the physical, chemical, and biological stability of this type of vaccine. 2010-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422010/690799null XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/An-Alternative-Platform-for-Rapid-Production-of-Ef/ArticleStandard/Article/detail/690797?contextCategoryId=39223&ref=25 Adjuvant activity can be greatly improved by appropriate formulation of cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs). 2010-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422010/690797null XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/Sterilizing-Filtration-of-Adjuvanted-Vaccines-Ensu/ArticleStandard/Article/detail/690798?contextCategoryId=39223&ref=25 Filterability and bacterial retention must be verified very early in process development to ensure successful sterilizing filtration validation. 2010-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422010/690798null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Regulatory-Challenges-Impede-the-Adoption-of-New-D/ArticleStandard/Article/detail/690804?contextCategoryId=39223&ref=25 Can vendor—user partnerships overcome the typical wait-and-see attitude toward new technologies? 2010-10-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422010/690804null XML http://www.biopharminternational.com/biopharm/Quality/Design-Space-Development-for-Lyophilization-Using-/ArticleStandard/Article/detail/685438?contextCategoryId=39223&ref=25 Develop a relevant design space without full factorial DoE. 2010-09-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/362010/685438/bp0910_Sundaram_flash.jpeg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Meningitis-Vaccine-Purification-Quality-Control-of/ArticleStandard/Article/detail/683152?contextCategoryId=39223&ref=25 How to balance porosity, plugging, and lot-to-lot variability in filters. 2010-08-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/332010/683152/bp0810_Lee_flash.jpeg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Technical-and-Economic-Benefits-of-Membrane-Chroma/ArticleStandard/Article/detail/683148?contextCategoryId=39223&ref=25 An analysis of flow rate, load density, viral clearance, and cost. 2010-08-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/332010/683148/bp0810_Fraud_flash.jpeg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Downstream-Disposables-The-Missing-Link-in-the-Dis/ArticleStandard/Article/detail/683155?contextCategoryId=39223&ref=25 Although single-use systems are widely used in upstream unit operations, their acceptance in downstream processes has been slow. 2010-08-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/332010/683155null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Large-Scale-Freezing-of-Biologics-Understanding-Pr/ArticleStandard/Article/detail/677311?contextCategoryId=39223&ref=25 2010-07-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/272010/677311/bp0710_Singh_flash.jpeg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Will-Protein-A-Be-the-Long-Term-Solution-for-Your-/ArticleStandard/Article/detail/672430?contextCategoryId=39223&ref=25 Biomanufacturers and vendors are now exploring more cost-effective purification technologies. 2010-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/232010/672430null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Large-Scale-Freezing-of-Biologics-Understanding-Pr/ArticleStandard/Article/detail/672433?contextCategoryId=39223&ref=25 2010-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/232010/672433/bp0610_Singh_flash.JPG XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Designing-in-Quality-Approaches-to-Defining-the-De/ArticleStandard/Article/detail/667241?contextCategoryId=39223&ref=25 How to use risk assessment strategies to integrate operations. 2010-05-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182010/667241/Bannerjee_flash.jpeg XML http://www.biopharminternational.com/biopharm/From+the+Editor/Pandemic-Response-Progress-and-Challenges/ArticleStandard/Article/detail/667239?contextCategoryId=39223&ref=25 We all know that experience is the best teacher. With H1N1, we have a great opportunity to learn important lessons. 2010-05-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182010/667239null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/A-Study-of-Leachables-for-Biopharmaceutical-Formul/ArticleStandard/Article/detail/663859?contextCategoryId=39223&ref=25 A systematic approach facilitates formulation component selection. 2010-04-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142010/663859/bp0410_Ding_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Developing-a-MAb-Aggregate-Removal-Step-by-High-Th/ArticleStandard/Article/detail/663860?contextCategoryId=39223&ref=25 HTPD allows rapid screening of chromatographic parameters. 2010-04-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142010/663860/bp0410_Rodrigo_flash.jpg XML http://www.biopharminternational.com/biopharm/Quality%2FGMP%2FValidation++Whitepapers/The-Challenge-of-Defining-the-Higher-Order-Structu/ArticleStandard/Article/detail/660222?contextCategoryId=39223&ref=25 Characterizing the higher order structure (HOS) of protein drugs increases manufacturers' understanding of stability and batch-to-batch variability, and may make it possible to link variants or aggregates to safety and efficacy. Yet at the January 24 CMC Strategy Forum in Washington, DC, regulators expressed concern that methods to characterize the three-dimensional structure of proteins are not routinely applied to biotechnology products. 2010-03-05T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/102010/660222null HTML http://www.biopharminternational.com/biopharm/Downstream+Processing/Mixed-Mode-Chromatography-in-Downstream-Process-De/ArticleStandard/Article/detail/659499?contextCategoryId=39223&ref=25 Salt-tolerant adsorption and unique selectivity are the major advantages of mixed-mode materials over single-mode resins. 2010-03-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/102010/659499null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/PEG-Precipitation-A-Powerful-Tool-for-Monoclonal-A/ArticleStandard/Article/detail/659496?contextCategoryId=39223&ref=25 This alternative purification method to chromatography is readily scalable and fits a fully disposable downstream process. 2010-03-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/102010/659496null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/The-Time-Value-of-Information-in-Designing-Downstr/ArticleStandard/Article/detail/659498?contextCategoryId=39223&ref=25 To speed up the downstream process, you must get the right data, in the right amount, at the right time. Here's how. 2010-03-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/102010/659498null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Advances-in-Monoclonal-Antibody-Purification/ArticleStandard/Article/detail/659497?contextCategoryId=39223&ref=25 New technologies and adaptations of existing technologies can improve platform processes. 2010-03-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/102010/659497null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Downstream-Processing-Promising-Technologies-are-o/ArticleStandard/Article/detail/659503?contextCategoryId=39223&ref=25 The new technologies being developed to improve downstream systems go beyond traditional chromatography. 2010-03-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/102010/659503null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Characterizing-the-Formulation-Design-Space/ArticleStandard/Article/detail/659506?contextCategoryId=39223&ref=25 Design of experiments is a valuable tool for identifying aspects of a formulation that are critical to product quality. 2010-03-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/102010/659506/bp0310_Grillo_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/The-Purification-of-Plasmid-DNA-for-Clinical-Trial/ArticleStandard/Article/detail/654418?contextCategoryId=39223&ref=25 Membrane chromatography ensures purity at high flow rates. 2010-02-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/052010/654418/bp0210_pDNA_purification_flash.jpg XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/Optimizing-Vaccine-Adjuvant-Filtration/ArticleStandard/Article/detail/650827?contextCategoryId=39223&ref=25 The viscosity of oily emulsions can reduce filter capacity and bacterial retention. 2010-01-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/022010/650827null XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/Influenza-Vaccine-Enhancement-with-Immunomodulatin/ArticleStandard/Article/detail/650826?contextCategoryId=39223&ref=25 Clinical studies have shown that treatment with thymosin alpha 1 increases response to vaccination. 2010-01-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/022010/650826null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Advancing-Adjuvants-and-Vaccine-Delivery-Systems-f/ArticleStandard/Article/detail/651187?contextCategoryId=39223&ref=25 This article presents ongoing research at VIDO-InterVac for the development of safer and more effective adjuvants. These include adjuvants that stimulate innate immunity in the body and combination adjuvants. 2010-01-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/032010/651187null HTML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/New-Approaches-to-Improved-Vaccine-Manufacturing-i/ArticleStandard/Article/detail/650825?contextCategoryId=39223&ref=25 Recombinant vector technologies can improve the yield and lower the cost of egg-based influenza vaccine production. 2010-01-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/022010/650825null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/The-Impact-of-Disposables-on-Project-Economics-in-/ArticleStandard/Article/detail/646884?contextCategoryId=39223&ref=25 A case study compares capital costs, operating expenses, and NPV for a new MAb plant. 2009-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492009/646884/bp1209_Chico_flash.jpg XML http://www.biopharminternational.com/biopharm/Quality%2FGMP%2FValidation++Whitepapers/To-FIT-or-Not-to-FIT-That-is-the-Question/ArticleStandard/Article/detail/640114?contextCategoryId=39223&ref=25 Conducting a FMEA analysis is a good first step in a risk-based approach for determining the need for a filter integrity test. 2009-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452009/640114/bp1109_filter_testing2_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Salt-Tolerant-Interaction-Chromatography-for-Large/ArticleStandard/Article/detail/633241?contextCategoryId=39223&ref=25 STIC allows polishing to be carried out without an interstitial dilution step, which reduces process time and avoids additional buffer preparation and hold steps. 2009-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422009/633241null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/The-Development-and-Application-of-a-Monoclonal-An/ArticleStandard/Article/detail/633292?contextCategoryId=39223&ref=25 A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies. 2009-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422009/633292null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Hydrophobic-Membrane-Adsorbers-for-Large-Scale-Dow/ArticleStandard/Article/detail/633242?contextCategoryId=39223&ref=25 This alternative to column chromatography is suitable for flow-through as well as bind-and-elute purification operations. 2009-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422009/633242null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/A-Purification-Platform-for-the-Production-of-MAbs/ArticleStandard/Article/detail/633291?contextCategoryId=39223&ref=25 New techniques can overcome bottlenecks in existing facilities. 2009-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422009/633291null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Economic-Drivers-and-Trade-Offs-in-Antibody-Purifi/ArticleStandard/Article/detail/633295?contextCategoryId=39223&ref=25 The future of therapeutic MAbs lies in the development of economically feasible downstream processes. 2009-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422009/633295null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Virus-Clearance-Strategy-Using-a-Three-Tier-Orthog/ArticleStandard/Article/detail/633293?contextCategoryId=39223&ref=25 How to implement a risk-based approach to eliminate viruses using orthogonal technologies. 2009-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422009/633293null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Precipitation-of-Process-Derived-Impurities-in-Non/ArticleStandard/Article/detail/633294?contextCategoryId=39223&ref=25 Precipitation prior to capture chromatography offers a simple, robust, and economical method to remove CHO host cell proteins and DNA. 2009-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422009/633294null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Antibody-Purification-Using-Membrane-Adsorbers/ArticleStandard/Article/detail/633290?contextCategoryId=39223&ref=25 A membrane adsorber in retention mode can be used efficiently in a commercial antibody manufacturing process. 2009-10-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/422009/633290null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/A-Closer-Look-at-Automated-In-Line-Dilution/ArticleStandard/Article/detail/632935?contextCategoryId=39223&ref=25 Automated in-line dilution can help solve capacity, financial, and quality concerns that biopharmaceutical manufacturing plants may be facing. 2009-10-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/412009/632935/BP1009_InLine_Dilution_flash.jpg XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/Addressing-Unmet-Medical-Needs-Through-Tailored-Va/ArticleStandard/Article/detail/633145?contextCategoryId=39223&ref=25 It is now possible to combine antigens with specific adjuvant systems to create more effective vaccines. 2009-10-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/412009/633145null XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/Pandemic-Preparedness-What-More-Can-We-Do/ArticleStandard/Article/detail/633147?contextCategoryId=39223&ref=25 The industry and government must collaborate to develop robust technologies and quicker, more flexible manufacturing approaches for vaccine development. 2009-10-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/412009/633147null XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/Tangential-Flow-Filtration-for-the-Recovery-of-Ace/ArticleStandard/Article/detail/633148?contextCategoryId=39223&ref=25 Membrane-based TFF technology can ease scale-up and provide a higher recovery percentage compared to conventional purification methods. 2009-10-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/412009/633148null XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/Innovations-in-Intranasal-Vaccine-Delivery-Technol/ArticleStandard/Article/detail/632937?contextCategoryId=39223&ref=25 Needle-free vaccine delivery platforms can solve the problems of stockpiling, cold-chain management, and pandemic preparedness. 2009-10-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/412009/632937null XML http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/Advancing-Vaccine-Technology-to-Combat-Global-Pand/ArticleStandard/Article/detail/633146?contextCategoryId=39223&ref=25 New technologies such as virus-like particles are promising weapons in the battle against pandemic influenza. 2009-10-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/412009/633146null XML http://www.biopharminternational.com/biopharm/Business/Downstream-Processing/ArticleStandard/Article/detail/627965?contextCategoryId=39223&ref=25 To assess current trends in separation and purification, BioPharm International turned to Mandar Dixit, head of product management?filtration technologies, Sartorius Stedim Biotech; Günter Jagschies, senior director of strategic customer relations, life sciences, biotechnologies, GE Healthcare; Richard Pearce, program director of purification, Millipore Corporation; and Jon Petrone, global technical director, Pall Life Sciences. 2009-09-21T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/392009/627965null HTML http://www.biopharminternational.com/biopharm/Downstream+Processing/The-Proper-Use-of-47-mm-Flat-Disc-Filters-in-Filte/ArticleStandard/Article/detail/624455?contextCategoryId=39223&ref=25 Why staining is crucial in flow decay studies. 2009-09-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/372009/624455/Bp0909_filter_sizing_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Comparison-of-Camelid-Antibody-Ligand-to-Protein-A/ArticleStandard/Article/detail/624453?contextCategoryId=39223&ref=25 A stable alternative to Protein A chromatography. 2009-09-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/372009/624453/bp0909_CamelidAntibody_Ligand_flash.jpg XML http://www.biopharminternational.com/biopharm/Quality/Analytical-Tools-for-Process-and-Product-Character/ArticleStandard/Article/detail/615148?contextCategoryId=39223&ref=25 Select the best approach to determine critical quality attributes. 2009-08-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/312009/615148/bp0809_analytical_tools_flash.jpg XML http://www.biopharminternational.com/biopharm/Downstream+Processing/Using-Metabolic-Profiling-Technology-to-Advance-Ce/ArticleStandard/Article/detail/601190?contextCategoryId=39223&ref=25 Through metabolomics, the metabolic underpinnings of cellular changes can be rapidly pinpointed, directing process development scientists to key areas for cell culture optimization. 2009-06-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/232009/601190null XML http://www.biopharminternational.com/biopharm/Downstream+Processing/The-Impact-of-Cell-Culture-Medium-on-Cell-Line-and/ArticleStandard/Article/detail/601146?contextCategoryId=39223&ref=25 ACF medium sped up cell-line development. 2009-06-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/232009/601146/bp0609s_culture_medium_flash.jpg XML