BioPharm International - Disposables http://www.biopharminternational.com/biopharm/Disposables/Article/list/35801 The advantages and disadvantages of disposables, along with cost-benefit analyses, validation strategies, and implementation approaches. 2013-05-19T02:32:53Z Ten Years Later: Innovation Driving Single-Use Technology Advances http://www.biopharminternational.com/biopharm/Feature+Rotating+Article/Ten-Years-Later-Innovation-Driving-Single-Use-Tech/ArticleStandard/Article/detail/810533?contextCategoryId=35801&ref=25 BioPlan's Annual Report shows continued growth in the use of single-use technology. 2013-04-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/152013/810533/bp0413supp_langer_t_thumbnail.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/152013/810533/bp0413supp_t_flash.jpg XML The Overlooked Benefits of Single-Use Technology: Improved Quality and Increased Patient Safety http://www.biopharminternational.com/biopharm/Quality/The-Overlooked-Benefits-of-Single-Use-Technology-I/ArticleStandard/Article/detail/810531?contextCategoryId=35801&ref=25 Reduced carryover risk and close attention to particulate control result in greater patient safety through the use of single-use systems. 2013-04-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/152013/810531null XML Scalability of the Mobius CellReady Single-use Bioreactor Systems http://www.biopharminternational.com/biopharm/Feature+Rotating+Article/Scalability-of-the-Mobius-CellReady-Single-use-Bio/ArticleStandard/Article/detail/810529?contextCategoryId=35801&ref=25 Review the process-design space and scalability of a single-use, stirred-tank bioreactor. 2013-04-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/152013/810529/bpsupp0413_mobius_thumbnail.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/152013/810529/bp0413_mobius_t_flash.jpg XML Making the Best Choices in Single-Use Tubing http://www.biopharminternational.com/biopharm/Disposables/Making-the-Best-Choices-in-Single-Use-Tubing/ArticleStandard/Article/detail/810532?contextCategoryId=35801&ref=25 Jerold Martin considers the types of tubing available to the industry and how to make an informed selection. 2013-04-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/152013/810532null XML Securing and Qualifying Single-Use Technologies http://www.biopharminternational.com/biopharm/Feature+Rotating+Article/Securing-and-Qualifying-Single-Use-Technologies/ArticleStandard/Article/detail/810534?contextCategoryId=35801&ref=25 The authors suggest techniques for mitigating risk and securing the supply chain for single-use components used in biopharmaceutical manufacturing. 2013-04-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/152013/810534null XML When the Process Becomes the Product: Single-Use Technology and the Next Biomanufacturing Paradigm http://www.biopharminternational.com/biopharm/Feature+Rotating+Article/When-the-Process-Becomes-the-Product-Single-Use-Te/ArticleStandard/Article/detail/810530?contextCategoryId=35801&ref=25 The move to single-use manufacturing has prompted a paradigm shift in facility design. 2013-04-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/152013/810530null XML Growth Kinetics of Human Mesenchymal Stem Cells in a 3-L Single-Use, Stirred-Tank Bioreactor http://www.biopharminternational.com/biopharm/Good+Manufacturing+Practices/Growth-Kinetics-of-Human-Mesenchymal-Stem-Cells-in/ArticleStandard/Article/detail/810545?contextCategoryId=35801&ref=25 The authors describe the growth characteristics of human mesenchymal stem cells cultured in a stirred-tank bioreactor. 2013-04-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/152013/810545null XML The Future of Biopharma http://www.biopharminternational.com/biopharm/Downstream+Processing/The-Future-of-Biopharma/ArticleStandard/Article/detail/802143?contextCategoryId=35801&ref=25 What the industry's future holds and what needs to be done to get there. 2013-01-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/022013/802143/BP0113_bp0113_136120148-1_web_flash.jpg XML Analyzing the Best Fit for a Facility http://www.biopharminternational.com/biopharm/Disposables/Analyzing-the-Best-Fit-for-a-Facility/ArticleStandard/Article/detail/796137?contextCategoryId=35801&ref=25 A brief case study of a facility-fit analysis provides insight into how to adjust capacity when moving from clinical-to commercial-scale production. 2012-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796137null XML Implementing a Single-Use TFF System in a cGMP Biomanufacturing Facility http://www.biopharminternational.com/biopharm/Disposables/Implementing-a-Single-Use-TFF-System-in-a-cGMP-Bio/ArticleStandard/Article/detail/796140?contextCategoryId=35801&ref=25 This case study describes the process used to transition from a multi-use system to single-use tangential flow filtration for performing final buffer exchange steps. 2012-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796140null XML Technical Forum: Disposable Chromatography http://www.biopharminternational.com/biopharm/Disposables/Technical-Forum-Disposable-Chromatography/ArticleStandard/Article/detail/796142?contextCategoryId=35801&ref=25 Industry experts from GE Healthcare, Tarpon Biosystems, Polybatics, Merck Millipore, and Repligen discuss the challenges of adapting disposable technology to the chromatography process. 2012-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796142null XML Upstream, Downstream Processing in Motion http://www.biopharminternational.com/biopharm/Downstream+Processing/Upstream-Downstream-Processing-in-Motion/ArticleStandard/Article/detail/796141?contextCategoryId=35801&ref=25 GE Healthcare Life Sciences' ReadyToProcess platform aims to streamline bioprocessing. 2012-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796141/GEHealthcareRTR_Interior_Web_flash.jpg XML The Challenges of Adopting Single-Use Technology http://www.biopharminternational.com/biopharm/Quality/The-Challenges-of-Adopting-Single-Use-Technology/ArticleStandard/Article/detail/796136?contextCategoryId=35801&ref=25 Insights on single-use systems implementation and exploitation in biopharmaceutical manufacturing and processing, based on a QbD approach. 2012-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796136null XML Development of a Full Process Train, Single-Use Facility http://www.biopharminternational.com/biopharm/Disposables/Development-of-a-Full-Process-Train-Single-Use-Fac/ArticleStandard/Article/detail/796139?contextCategoryId=35801&ref=25 This article describes best practices for implementing a single-use process train at a bioproduction facility. 2012-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796139null XML Aligning Manufacturing and Business Strategies with Single-Use Systems http://www.biopharminternational.com/biopharm/Disposables/Aligning-Manufacturing-and-Business-Strategies-wit/ArticleStandard/Article/detail/796135?contextCategoryId=35801&ref=25 The authors explain why Catalent decided to transition from stainless steel to single-use systems. 2012-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796135/Catalent_Open-Art-Image_Web_flash.jpg XML Integration of a Single-Use Platform Process within an Innovative Facility Design http://www.biopharminternational.com/biopharm/Disposables/Integration-of-a-Single-Use-Platform-Process-withi/ArticleStandard/Article/detail/796138?contextCategoryId=35801&ref=25 The combination of single-use platform technology with modular facility construction is a template for flexible manufacturing. 2012-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796138null XML It's an Election Year.... Are You Making the Best Choices in Single-Use Tubing http://www.biopharminternational.com/biopharm/Disposables+Advisor/Its-an-Election-Year-Are-You-Making-the-Best-Choic/ArticleStandard/Article/detail/796143?contextCategoryId=35801&ref=25 The author considers the types of tubing available to the industry and how to make an informed selection. 2012-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452012/796143null XML 25 Years of Biopharmaceutical Innovation: An Expert Roundtable http://www.biopharminternational.com/biopharm/Quality/25-Years-of-Biopharmaceutical-Innovation-An-Expert/ArticleStandard/Article/detail/775157?contextCategoryId=35801&ref=25 Industry experts discuss significant achievements. Plus: What's in store for the future. 2012-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/212012/775157/BP0612_54_Covers-1988_Jan_flash.jpg XML 25 Years of BioPharma Industry Growth http://www.biopharminternational.com/biopharm/Quality/25-Years-of-BioPharma-Industry-Growth/ArticleStandard/Article/detail/775160?contextCategoryId=35801&ref=25 A review of key industry shifts and promises for the future. 2012-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/212012/775160/BP0612_21_140654677-2-Duotone_flash.jpg XML Understanding Gamma Sterilization http://www.biopharminternational.com/biopharm/Disposables+Advisor/Understanding-Gamma-Sterilization/ArticleStandard/Article/detail/757930?contextCategoryId=35801&ref=25 This article outlines methods, validation standards, and documentation of sterilization of single-use products using gamma irradiation. 2012-02-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/062012/757930null XML A 25-Year Retrospective on Separations Technology http://www.biopharminternational.com/biopharm/Quality/A-25-Year-Retrospective-on-Separations-Technology/ArticleStandard/Article/detail/754428?contextCategoryId=35801&ref=25 This month, we rewind to "Separations Technology Outlook, Part II: Improved Recovery and Greater Purity." 2012-01-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/532011/754428null XML Methods for the Automated Manufacturing of an Autologous Dendritic-Cell Immunotherapy http://www.biopharminternational.com/biopharm/Disposables/Methods-for-the-Automated-Manufacturing-of-an-Auto/ArticleStandard/Article/detail/750860?contextCategoryId=35801&ref=25 The author describes automated equipment that uses functionally closed disposables. 2011-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492011/750860/BP1211_54_DendriticCellFig4_web_flash.jpg XML The Employment Outlook Brightens http://www.biopharminternational.com/biopharm/Quality%2FGMP%2FValidation++Whitepapers/The-Employment-Outlook-Brightens/ArticleStandard/Article/detail/750859?contextCategoryId=35801&ref=25 Readers react to the economic turmoil of the past year and look longingly forward to 2012. 2011-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492011/750859/BP1211_22_103772148_web_flash.jpg XML An Environmental Life Cycle Assessment Comparing Single-Use and Conventional Process Technology http://www.biopharminternational.com/biopharm/Disposables/An-Environmental-Life-Cycle-Assessment-Comparing-S/ArticleStandard/Article/detail/746269?contextCategoryId=35801&ref=25 The authors compare the environmental impact of monoclonal antibody production using fixed-in-place processing and single-use systems. 2011-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442011/746269null XML A Brief History of Single-Use Manufacturing http://www.biopharminternational.com/biopharm/Disposables/A-Brief-History-of-Single-Use-Manufacturing/ArticleStandard/Article/detail/746267?contextCategoryId=35801&ref=25 Single-use manufacturing may seem like a new trend, but it has actually been around for almost 30 years, beginning in the early 1980s when filter manufacturers began to make small process-scale plastic filter capsules to replace "junior" size stainless-filter housing assemblies. 2011-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442011/746267null XML Emerging Bioprocessing Methods http://www.biopharminternational.com/biopharm/Disposables/Emerging-Bioprocessing-Methods/ArticleStandard/Article/detail/746268?contextCategoryId=35801&ref=25 New technology is designed to improve production efficiency by taking advantage of the properties of single-use bags. 2011-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442011/746268/BP1111_Niazi_Figure1_web_flash.jpg XML Approaches for Flexible Manufacturing Facilities in Vaccine Production http://www.biopharminternational.com/biopharm/Disposables/Approaches-for-Flexible-Manufacturing-Facilities-i/ArticleStandard/Article/detail/746266?contextCategoryId=35801&ref=25 With careful analysis to mitigate risk, disposable technology and process closure can enable adaptable designs and reduced costs. 2011-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442011/746266null XML The Evolution from Fixed to Single-Use Systems http://www.biopharminternational.com/biopharm/Disposables/The-Evolution-from-Fixed-to-Single-Use-Systems/ArticleStandard/Article/detail/746270?contextCategoryId=35801&ref=25 An overview of applications for disposable components and important property considerations. 2011-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442011/746270/Bp1111_KynarRXBag_web_flash.jpg XML Integrity Testing of Flexible Containers http://www.biopharminternational.com/biopharm/Quality/Integrity-Testing-of-Flexible-Containers/ArticleStandard/Article/detail/747047?contextCategoryId=35801&ref=25 Defects as small as 10 μm can be detected without compromising product cleanliness using helium integrity testing. 2011-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452011/747047null XML CMOs Ratchet up use of Single-Use Devices to Improve Performance http://www.biopharminternational.com/biopharm/Quality/CMOs-Ratchet-up-use-of-Single-Use-Devices-to-Impro/ArticleStandard/Article/detail/746278?contextCategoryId=35801&ref=25 Single-use systems continue to gain traction among biomanufacturers, especially CMOs. 2011-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442011/746278/BP1111_Cvr_T_Web2_flash.jpg XML Focus on Standardization, Quality by Design, and Regulatory GMP http://www.biopharminternational.com/biopharm/Quality/Focus-on-Standardization-Quality-by-Design-and-Reg/ArticleStandard/Article/detail/746282?contextCategoryId=35801&ref=25 In this quarter's column, highlights from the IBC Single-use Applications meeting, the PDA Single-use Workshop, and the BioProcess systems Alliance International Single-Use Summit are presented. 2011-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442011/746282null XML Navigating the Biosimilars Market http://www.biopharminternational.com/biopharm/Quality/Navigating-the-Biosimilars-Market/ArticleStandard/Article/detail/737344?contextCategoryId=35801&ref=25 The market landscape for biosimilars is in flux, with limited penetration now, but with the potential for growth for those who can navigate the market. Plus: A SWOT analysis of biosimilars by Anjan Selz. 2011-09-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/352011/737344null XML Single-use Technology: Balancing the Risks and Rewards http://www.biopharminternational.com/biopharm/Quality/Single-use-Technology-Balancing-the-Risks-and-Rewa/ArticleStandard/Article/detail/737342?contextCategoryId=35801&ref=25 Developing a quality agreement template for single-use systems. 2011-09-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/352011/737342null XML Particulate Quality of Single-Use Filling Systems http://www.biopharminternational.com/biopharm/Disposables+Advisor/Particulate-Quality-of-Single-Use-Filling-Systems/ArticleStandard/Article/detail/733330?contextCategoryId=35801&ref=25 The author looks at strategies to minimize particle levels in the finished product when using single-use technologies downstream of final capabilities. 2011-08-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/312011/733330null XML Biopharmaceutical Manufacturing Using Blow–Fill–Seal Technology http://www.biopharminternational.com/biopharm/Feature+Rotating+Article/Biopharmaceutical-Manufacturing-Using-BlowndashFil/ArticleStandard/Article/detail/728235?contextCategoryId=35801&ref=25 The authors give special consideration factors affecting blow–fill–seal technology. 2011-07-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/262011/728235/BP_0711_Cover-Image_web_flash.jpg XML Single-Use Technologies World Tour http://www.biopharminternational.com/biopharm/Disposables+Advisor/Single-Use-Technologies-World-Tour/ArticleStandard/Article/detail/724375?contextCategoryId=35801&ref=25 Single-use conference roundup. 2011-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/222011/724375null XML Increasing Efficiency in Protein and Cell Production by Combining Single-Use Bioreactor Technology and Perfusion http://www.biopharminternational.com/biopharm/Disposables/Increasing-Efficiency-in-Protein-and-Cell-Producti/ArticleStandard/Article/detail/718080?contextCategoryId=35801&ref=25 An off-the-shelf, single-use perfusion system. 2011-05-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182011/718080/bp0511_Sartorius.web_flash.jpg XML How Multipurpose is a Disposable Bioreactor? http://www.biopharminternational.com/biopharm/Disposables/How-Multipurpose-is-a-Disposable-Bioreactor/ArticleStandard/Article/detail/711067?contextCategoryId=35801&ref=25 The authors discuss the use of single-use bioreactors. 2011-03-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/112011/711067/BP0311Bergweb_flash.jpg XML Trends Toward Standardization http://www.biopharminternational.com/biopharm/Disposables+Advisor/Trends-Toward-Standardization/ArticleStandard/Article/detail/707018?contextCategoryId=35801&ref=25 Although some aspects of single-use components can be standardized, it is unlikely that any materials or design features will become a commodity 2011-02-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/072011/707018null XML Implementing Disposables Technology, Delivering Innovation, and Transforming an Organization http://www.biopharminternational.com/biopharm/Disposables+Advisor/Implementing-Disposables-Technology-Delivering-Inn/ArticleStandard/Article/detail/698527?contextCategoryId=35801&ref=25 Sanofi Pasteur's disposables implementation plan is part of a larger evaluation of technology innovation. Here's how they approach it. 2010-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492010/698527null XML Regulatory Expectations and Consensus Industry Recommendations for Extractables Testing of Single-Use Process Equipment http://www.biopharminternational.com/biopharm/Disposables/Regulatory-Expectations-and-Consensus-Industry-Rec/ArticleStandard/Article/detail/695154?contextCategoryId=35801&ref=25 BPSA eases confusion over extractables and leachables testing through guides. 2010-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462010/695154null XML Disposable Bioreactors for Viral Vaccine Production: Challenges and Opportunities http://www.biopharminternational.com/biopharm/Disposables/Disposable-Bioreactors-for-Viral-Vaccine-Productio/ArticleStandard/Article/detail/695153?contextCategoryId=35801&ref=25 Switching to single-use bioreactors can have financial and performance benefits. 2010-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462010/695153null XML Evaluation of a Single-Use Bioreactor for the Fed-Batch Production of a Monoclonal Antibody http://www.biopharminternational.com/biopharm/Disposables/Evaluation-of-a-Single-Use-Bioreactor-for-the-Fed-/ArticleStandard/Article/detail/695157?contextCategoryId=35801&ref=25 Despite different material, agitation, and aeration, the performance of the disposable bioreactor is similar to that of stainless steel bioreactors. 2010-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462010/695157null XML Implementing Single-Use Technology in Tangential Flow Filtration Systems in Clinical Manufacturing http://www.biopharminternational.com/biopharm/Disposables/Implementing-Single-Use-Technology-in-Tangential-F/ArticleStandard/Article/detail/695156?contextCategoryId=35801&ref=25 A case study evaluates the performance, control of operations, productivity, and cost savings of a single-use system. 2010-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462010/695156null XML An Economic Analysis of Single-Use Tangential Flow Filtration for Biopharmaceutical Applications http://www.biopharminternational.com/biopharm/Disposables/An-Economic-Analysis-of-Single-Use-Tangential-Flow/ArticleStandard/Article/detail/695155?contextCategoryId=35801&ref=25 Single-use TFF offers the greatest savings in clinical and contract manufacturing, where the scale is low and changeovers are frequent. 2010-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462010/695155null XML Downstream Disposables: The Missing Link in the Disposables Chain http://www.biopharminternational.com/biopharm/Downstream+Processing/Downstream-Disposables-The-Missing-Link-in-the-Dis/ArticleStandard/Article/detail/683155?contextCategoryId=35801&ref=25 Although single-use systems are widely used in upstream unit operations, their acceptance in downstream processes has been slow. 2010-08-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/332010/683155null XML Disposable Systems as a Platform Technology for R&D and Clinical Supply http://www.biopharminternational.com/biopharm/Disposables+Advisor/Disposable-Systems-as-a-Platform-Technology-for-Ra/ArticleStandard/Article/detail/683154?contextCategoryId=35801&ref=25 How a Big Pharma company tackled the move to disposable bioreactors. 2010-08-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/332010/683154null XML Resources http://www.biopharminternational.com/biopharm/Quality/Resources/ArticleStandard/Article/detail/654739?contextCategoryId=35801&ref=25 If you are looking for additional information (or terms not included in our glossary), here are some places to begin your search. 2010-02-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/062010/654739null XML Podcast Series http://www.biopharminternational.com/biopharm/Quality/Podcast-Series/ArticleStandard/Article/detail/654741?contextCategoryId=35801&ref=25 UPLC, QTof, HDMS, and more: A practical guide to the hottest techniques driving the future of biopharmaceutical science. 2010-02-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/062010/654741null XML Bioterminology http://www.biopharminternational.com/biopharm/Quality/Bioterminology/ArticleStandard/Article/detail/654740?contextCategoryId=35801&ref=25 A Guide to the Biopharmaceutical Lexicon, 2010 edition 2010-02-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/062010/654740null XML End-to-End Deployment of Single-Use Technology in Aseptic Filling of Vaccines at GSK http://www.biopharminternational.com/biopharm/Disposables+Advisor/End-to-End-Deployment-of-Single-Use-Technology-in-/ArticleStandard/Article/detail/654421?contextCategoryId=35801&ref=25 How this Big Pharma company successfully implemented disposable technologies in its manufacturing plant. 2010-02-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/052010/654421null XML Disposables in Rapid Response Manufacturing: The Next Steps http://www.biopharminternational.com/biopharm/Disposables+Advisor/Disposables-in-Rapid-Response-Manufacturing-The-Ne/ArticleStandard/Article/detail/646885?contextCategoryId=35801&ref=25 Suppliers, manufacturers, and governments must work together to plan how best to develop and deploy disposable systems for emergency response. 2009-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492009/646885null XML Freeze-Thaw Performance and Robustness Assessment of Celsius FFT 6L http://www.biopharminternational.com/biopharm/Disposables/Freeze-Thaw-Performance-and-Robustness-Assessment-/ArticleStandard/Article/detail/646889?contextCategoryId=35801&ref=25 A case study assesses freezing time and physical robustness under stress. 2009-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492009/646889/bp1209_Voute_flash.jpg XML Freeze Bulk Bags: A Case Study in Disposables Implementation http://www.biopharminternational.com/biopharm/Disposables/Freeze-Bulk-Bags-A-Case-Study-in-Disposables-Imple/ArticleStandard/Article/detail/637583?contextCategoryId=35801&ref=25 Genentech's evaluation of single-use technologies for bulk freeze-thaw, storage, and transportation. 2009-11-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442009/637583null XML A Review of Sterile Connectors http://www.biopharminternational.com/biopharm/Disposables/A-Review-of-Sterile-Connectors/ArticleStandard/Article/detail/637917?contextCategoryId=35801&ref=25 Many factors must be considered when choosing a sterile connector for a given process. 2009-11-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442009/637917null XML Scale-Up and Comparison Studies Evaluating Disposable Bioreactors and Probes http://www.biopharminternational.com/biopharm/Disposables/Scale-Up-and-Comparison-Studies-Evaluating-Disposa/ArticleStandard/Article/detail/637918?contextCategoryId=35801&ref=25 Process performance was comparable across all scales, and fiber optic sensors appeared interchangeable with conventional probes. 2009-11-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442009/637918null XML Integrating Single-Use Connection Components into Filter Integrity Testing Reduces Manufacturing Risk http://www.biopharminternational.com/biopharm/Disposables/Integrating-Single-Use-Connection-Components-into-/ArticleStandard/Article/detail/637585?contextCategoryId=35801&ref=25 Single-use connections can help drug manufacturers maximize efficiency in every step of the manufacturing process. 2009-11-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/442009/637585null XML Single-Use Bioprocessing Equipment http://www.biopharminternational.com/biopharm/Business/Single-Use-Bioprocessing-Equipment/ArticleStandard/Article/detail/627768?contextCategoryId=35801&ref=25 To assess current trends in single-use bioprocessing equipment, BioPharm International turned to John Boehm, bioprocessing business unit manager, Colder Products Company; Mandar Dixit, head of product management?filtration technologies, Sartorius Stedim Biotech; Geoff Hodge, managing director of process technology Xcellerex, Inc.; Günter Jagschies, senior director of strategic customer relations, life sciences, biotechnologies, GE Healthcare; Mani Krishnan, director of product management, Mobius single-use technologies, Millipore Corporation; and Jerry Martin, senior vice president of scientific affairs, Pall Life Sciences, and board chairman and technology chair at BPSA. 2009-09-18T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/382009/627768null HTML Laboratory Equipment http://www.biopharminternational.com/biopharm/Business/Laboratory-Equipment/ArticleStandard/Article/detail/627754?contextCategoryId=35801&ref=25 To assess current trends in laboratory equipment, BioPharm International turned to Francis Bach, North American sales director, Asahi Kasei TechniKrom, Inc.; Erika Lapinskas, PhD, product manager, Sartorius Stedim Biotech; Jeffrey R. Mazzeo, PhD, biopharmaceutical business director, Waters Corporation; Amber Ratcliff, product manager, analytical sensors, Hamilton Company; and Josh Silverstone, marketing director, Millipore Corp. 2009-09-18T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/382009/627754null HTML The Role of Disposables in Rapid Response Manufacturing http://www.biopharminternational.com/biopharm/Disposables+Advisor/The-Role-of-Disposables-in-Rapid-Response-Manufact/ArticleStandard/Article/detail/615154?contextCategoryId=35801&ref=25 Single-use technologies can be configured and installed fairly quickly, but are they ready to handle the urgency and scale of a pandemic? 2009-08-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/312009/615154null XML User Viewpoints on Disposables Implementation http://www.biopharminternational.com/biopharm/Disposables+Advisor/User-Viewpoints-on-Disposables-Implementation/ArticleStandard/Article/detail/601411?contextCategoryId=35801&ref=25 What end users think about single-use systems. 2009-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/232009/601411null XML Disposables Cost Contributions: A Sensitivity Analysis http://www.biopharminternational.com/biopharm/Disposables+Advisor/Disposables-Cost-Contributions-A-Sensitivity-Analy/ArticleStandard/Article/detail/590348?contextCategoryId=35801&ref=25 Cost modeling provides valuable insights to support strategic decision-making when implementing disposable technologies. 2009-04-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142009/590348null XML Versatility of a Single-Use Bioreactor Platform for Culture of Diverse Cell Types http://www.biopharminternational.com/biopharm/Disposables/Versatility-of-a-Single-Use-Bioreactor-Platform-fo/ArticleStandard/Article/detail/580776?contextCategoryId=35801&ref=25 Are disposable bioreactors effective for cell culture? 2009-02-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/072009/580776/bp0209_single_use_bioreactor_flash.jpg XML Evaluating Disposable Mixing Systems http://www.biopharminternational.com/biopharm/Disposables+Advisor/Evaluating-Disposable-Mixing-Systems/ArticleStandard/Article/detail/580775?contextCategoryId=35801&ref=25 How to choose a disposable mixing system that fits your particular needs. 2009-02-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/072009/580775null XML An Alternative to the Scale-up and Distribution of Pandemic Influenza Vaccine http://www.biopharminternational.com/biopharm/Vaccine+Manufacturing+Articles/An-Alternative-to-the-Scale-up-and-Distribution-of/ArticleStandard/Article/detail/575563?contextCategoryId=35801&ref=25 With virus-based production, vaccines can be available in 10-12 weeks. 2009-01-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/032009/575563/bp0109s_virus_like_particle_flash.jpg XML Disposable Technologies Implementation: Understanding and Managing Risks http://www.biopharminternational.com/biopharm/Disposables+Advisor/Disposable-Technologies-Implementation-Understandi/ArticleStandard/Article/detail/568931?contextCategoryId=35801&ref=25 In new disposables projects, it is critical that engineering, procurement, and operations groups work together early on to manage supply chain risk. 2008-12-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/492008/568931null XML Disposables for Bioprocessing: Making the Transition http://www.biopharminternational.com/biopharm/Disposables/Disposables-for-Bioprocessing-Making-the-Transitio/ArticleStandard/Article/detail/566013?contextCategoryId=35801&ref=25 Transitioning from stainless steel technology to disposable technology in bioprocessing. 2008-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462008/566013null XML Lifecycle Cost Analysis for Single-Use Systems http://www.biopharminternational.com/biopharm/Disposables/Lifecycle-Cost-Analysis-for-Single-Use-Systems/ArticleStandard/Article/detail/566011?contextCategoryId=35801&ref=25 This article describes a quick method for evaluating lifecycle costs for single-use systems against their more conventional stainless-steel counterparts. 2008-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462008/566011null XML Systematic Evaluation of Single-Use Systems Using Process Simulation Tools http://www.biopharminternational.com/biopharm/Disposables/Systematic-Evaluation-of-Single-Use-Systems-Using-/ArticleStandard/Article/detail/566015?contextCategoryId=35801&ref=25 This article describes the steps required to build a comprehensive model in a batch process simulator for a process that uses single-use systems for buffer preparation and storage. 2008-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462008/566015null XML The Environmental Impact of Disposable Technologies http://www.biopharminternational.com/biopharm/Disposables/The-Environmental-Impact-of-Disposable-Technologie/ArticleStandard/Article/detail/566014?contextCategoryId=35801&ref=25 Can disposables reduce your facility's environmental footprint? We have compared the environmental footprint of a traditional biopharmaceutical manufacturing facility using fixed-in-place stainless steel equipment, and a facility implementing disposable technologies for cell culture, solution mixing and hold, product hold, and liquid transfer. 2008-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462008/566014null XML Disposable Bioreactors for Cells and Microbes http://www.biopharminternational.com/biopharm/Disposables/Disposable-Bioreactors-for-Cells-and-Microbes/ArticleStandard/Article/detail/566012?contextCategoryId=35801&ref=25 Productivities similar to those achieved with stirred tanks can be achieved with disposable bioreactors. 2008-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462008/566012null XML The Challenges and Benefits of Disposable Technologies http://www.biopharminternational.com/biopharm/Disposables/The-Challenges-and-Benefits-of-Disposable-Technolo/ArticleStandard/Article/detail/566026?contextCategoryId=35801&ref=25 Interview with David Radspinner, director of global marketing & customer applications, bioprocess production at Thermo Fisher Scientific. 2008-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462008/566026null XML The Environmental Impact of Disposables http://www.biopharminternational.com/biopharm/From+the+Editor/The-Environmental-Impact-of-Disposables/ArticleStandard/Article/detail/566016?contextCategoryId=35801&ref=25 Despite creating plastic waste, the disposables option is better for the environment. 2008-11-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462008/566016null XML Disposable Decisions http://www.biopharminternational.com/biopharm/Operations/Disposable-Decisions/ArticleStandard/Article/detail/557242?contextCategoryId=35801&ref=25 To achieve the right balance between disposable and reuseable options, companies must consider important technical and economic factors. 2008-10-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/412008/557242null XML Disposables Open Up Possibilities in Facility Design http://www.biopharminternational.com/biopharm/Disposables+Advisor/Disposables-Open-Up-Possibilities-in-Facility-Desi/ArticleStandard/Article/detail/532051?contextCategoryId=35801&ref=25 In addition to making technical developments, vendors are also looking at ways to improve supply-chain security. By offering standard, off-the-shelf products, vendors are able to shorten lead times and improve the security of supply. 2008-08-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/312008/532051null XML How to Evaluate the Cost Impact of Using Disposables in Biomanufacturing http://www.biopharminternational.com/biopharm/Disposables+Advisor/How-to-Evaluate-the-Cost-Impact-of-Using-Disposabl/ArticleStandard/Article/detail/522179?contextCategoryId=35801&ref=25 The current focus on cost-of-goods (COGS) models is underplaying the benefits of disposables technology in biopharmaceutical manufacturing. The best method for accounting for the benefits of reduced and delayed capital expenditures is through the use of NPV analysis. 2008-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/232008/522179null XML Disposable Bioreactors: The Next Generation http://www.biopharminternational.com/biopharm/Disposables+Advisor/Disposable-Bioreactors-The-Next-Generation/ArticleStandard/Article/detail/507470?contextCategoryId=35801&ref=25 Disposable technologies that mimic the conventional stainless-steel bioreactor will be most readily adopted 2008-04-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142008/507470null XML Extractables and Leachables Study Approach for Disposable Materials Used in Bioprocessing http://www.biopharminternational.com/biopharm/Disposables/Extractables-and-Leachables-Study-Approach-for-Dis/ArticleStandard/Article/detail/490803?contextCategoryId=35801&ref=25 Two case studies illustrate a systematic approach. 2008-02-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/072008/490803/ding_flash.jpg XML Single-Use Technologies—A Contract Biomanufacturer's Perspective http://www.biopharminternational.com/biopharm/Disposables/Single-Use-TechnologiesmdashA-Contract-Biomanufact/ArticleStandard/Article/detail/473325?contextCategoryId=35801&ref=25 One of the challenges of adopting single-use technology is that not all cell lines are compatible with disposable bioreactors. 2007-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462007/473325null XML A Next Step in Implementing Disposables: Transfer Lines http://www.biopharminternational.com/biopharm/Disposables/A-Next-Step-in-Implementing-Disposables-Transfer-L/ArticleStandard/Article/detail/473326?contextCategoryId=35801&ref=25 Single-use systems reduce maintenance and capital expense by eliminating expensive vessels, valves, and sanitary piping assemblies. 2007-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462007/473326null XML Antibody Purification with an Integrated Disposable Assembly http://www.biopharminternational.com/biopharm/Disposables/Antibody-Purification-with-an-Integrated-Disposabl/ArticleStandard/Article/detail/473324?contextCategoryId=35801&ref=25 Comparison of the integrated assembly purified MGG to the control revealed that the purity if the MGG was very high. 2007-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462007/473324null XML Design and Testing of a Prototype Large-Scale Bag Freeze–Thaw System http://www.biopharminternational.com/biopharm/Disposables/Design-and-Testing-of-a-Prototype-Large-Scale-Bag-/ArticleStandard/Article/detail/473322?contextCategoryId=35801&ref=25 A solution for the problems of a "bag in a can" system would be a fully jacketed and insulated container, similar to a traditional freeze tank. 2007-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462007/473322null XML Disposable Process for cGMP Manufacture of Plasmid DNA http://www.biopharminternational.com/biopharm/Disposables/Disposable-Process-for-cGMP-Manufacture-of-Plasmid/ArticleStandard/Article/detail/473323?contextCategoryId=35801&ref=25 Disposables are increasingly being used in the manufacture of biopharmaceuticals. This article describes the design of a fully disposable process for the cGMP manufacture of clinical trial grade plasmid DNA. It addresses the rationale for implementing such a process with respect to the manufacture of patient-specific plasmid DNA vaccines for the treatment of leukemia. The process incorporates a number of disposable technologies, which are simple to use and thus reduce the need for investment in expensive equipment and cleaning validation. 2007-11-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/462007/473323null XML Cell-Culture–Based Manufacturing: Meeting the Challenge of 21st Century Influenza http://www.biopharminternational.com/biopharm/Article/Cell-CulturendashBased-Manufacturing-Meeting-the-C/ArticleStandard/Article/detail/444991?contextCategoryId=35801&ref=25 Vaccines against strains originating from avian flu may achieve poor yields in egg-based systems. Consequently, both public and private interest in alternative systems is high. 2007-08-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/312007/444991null XML Pandemic Flu Preparedness: A Manufacturing Perspective http://www.biopharminternational.com/biopharm/Article/Pandemic-Flu-Preparedness-A-Manufacturing-Perspect/ArticleStandard/Article/detail/444990?contextCategoryId=35801&ref=25 For pandemic vaccine processing, single-use filter cartridges and membrane chromatography technologies could offer significant time- and cost-reduction advantages. 2007-08-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/312007/444990null XML Manufacturing Vaccines in Adherent Cell Lines Using Disposable Multi-tray Bioreactors http://www.biopharminternational.com/biopharm/Article/Manufacturing-Vaccines-in-Adherent-Cell-Lines-Usin/ArticleStandard/Article/detail/444994?contextCategoryId=35801&ref=25 The recent growth in the vaccine market has led to renewed interest in using adherent human cell lines for vaccine production. Traditionally, small-scale adherent cell line production has been carried out in roller bottles or T-flasks. Over the past few years, however, a number of companies have found multi-tray disposable bioreactors an effective method for producing high-quality drug products using adherent cells. These disposable, expandable systems have also facilitated scale up from laboratory to clinical-scale. 2007-08-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/312007/444994null XML Disposables: Biopharmaceutical Disposables as a Disruptive Future Technology http://www.biopharminternational.com/biopharm/Article/Disposables-Biopharmaceutical-Disposables-as-a-Dis/ArticleStandard/Article/detail/432391?contextCategoryId=35801&ref=25 Today, most disposables are used for process development and clinical-scale manufacturing. Substantial growth in disposables usage may not occur until disposables are incorporated into the production of licensed products at commercial scale. 2007-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/232007/432391/disposables_thumbnail.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/232007/432391null XML Disposable Bioreactors Based on Wave Agitation Technology http://www.biopharminternational.com/biopharm/Article/Disposable-Bioreactors-Based-on-Wave-Agitation-Tec/ArticleStandard/Article/detail/423196?contextCategoryId=35801&ref=25 Energy input is affected by rocking the chamber back and forth, generating a fluid movement in the cell culture and medium. 2007-05-02T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182007/423196null XML Separation & Purification: Endotoxin Reduction Using Disposable Membrane Adsorption Technology in cGMP Manufacturing http://www.biopharminternational.com/biopharm/Article/Separation-amp-Purification-Endotoxin-Reduction-Us/ArticleStandard/Article/detail/423190?contextCategoryId=35801&ref=25 Membrane-based chromatography technologies sometimes offer advantages over resin-based technologies. 2007-05-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182007/423190/chromatography_thumbnail.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182007/423190null XML Disposables: Keeping Pace with Today's Disposable Processing Applications http://www.biopharminternational.com/biopharm/Article/Disposables-Keeping-Pace-with-Todays-Disposable-Pr/ArticleStandard/Article/detail/415834?contextCategoryId=35801&ref=25 Frequently asked questions on implementing and using single-use technologies 2007-04-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142007/415834/disposables_thumbnail.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/142007/415834null XML From the Editor: The Industry's Disposition Toward Disposables http://www.biopharminternational.com/biopharm/Article/From-the-Editor-The-Industrys-Disposition-Toward-D/ArticleStandard/Article/detail/407869?contextCategoryId=35801&ref=25 Disposables are no longer a mistrusted new technology; they're seen as a potential solution to everyday problems. 2007-03-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/092007/407869null XML Scaling Up Disposable Membrane Chromatography http://www.biopharminternational.com/biopharm/Article/Scaling-Up-Disposable-Membrane-Chromatography/ArticleStandard/Article/detail/384808?contextCategoryId=35801&ref=25 In recent years, disposable membrane chromatography has gained acceptance as a robust device for large-scale processing. 2006-11-09T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/452006/384808null HTML Disposables in the Quality Control Laboratory http://www.biopharminternational.com/biopharm/Quality/Disposables-in-the-Quality-Control-Laboratory/ArticleStandard/Article/detail/423543?contextCategoryId=35801&ref=25 The deliberate reuse of disposables has caused many clinically significant problems. 2006-11-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182007/423543null XML Successful Project Management for Implementing Single-Use Bioprocessing Systems http://www.biopharminternational.com/biopharm/Article/Successful-Project-Management-for-Implementing-Sin/ArticleStandard/Article/detail/423544?contextCategoryId=35801&ref=25 In its early days, the biotech industry was almost entirely science driven, but it has since expanded from a laboratory environment to a sophisticated and dynamic manufacturing environment. As technological discoveries are increasingly translated into commercial products, biotech companies are realizing that they must generate a stronger return on assets. 2006-11-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182007/423544null XML Disposable Biopharmaceutical Processes–Myth or Reality? http://www.biopharminternational.com/biopharm/Article/Disposable-Biopharmaceutical-ProcessesndashMyth-or/ArticleStandard/Article/detail/423540?contextCategoryId=35801&ref=25 Biopharmaceutical processes typically require a significant investment in equipment—often a substantial obstacle for start-up companies. The risk of drug development failure is often high, further limiting access to the required capital. Flexibility and lower capital outlays are required not only by start-up companies, but also by research organizations with multiple product lines and by companies requiring quick capacity increases. Disposable technologies offer the highest potential for these companies to meet their business requirements. With lower capital requirements and increased flexibility, disposables are an important part of these companies' risk management strategy. 2006-11-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182007/423540null XML Properties of Materials Used in Single-Use Flexible Containers: Requirements and Analysis http://www.biopharminternational.com/biopharm/Article/Properties-of-Materials-Used-in-Single-Use-Flexibl/ArticleStandard/Article/detail/423541?contextCategoryId=35801&ref=25 The adoption of single-use containers in the biopharmaceutical industry is becoming more frequent as the popularity and availability of the technologies increase. The choice of a solution for storage in single-use containers clearly depends on the application and the inherent risks associated with the application. A "one fits all" single-use system cannot respond to all the requirements of a particular step in a biopharmaceutical process, much less to all the steps of a process. The needs of an application will lead to very specific single-use solutions. 2006-11-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182007/423541null XML Simplifying Validation of Disposable Technologies with Presterilization by Gamma Irradiation http://www.biopharminternational.com/biopharm/Article/Simplifying-Validation-of-Disposable-Technologies-/ArticleStandard/Article/detail/423542?contextCategoryId=35801&ref=25 Filtration systems exemplify disposable technologies that can be presterilized. 2006-11-02T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/182007/423542null XML Production Cost Analysis: Economic Analysis as a tool for Process Development: Harvest of a High Cell-Density Fermentation http://www.biopharminternational.com/biopharm/Article/Production-Cost-Analysis-Economic-Analysis-as-a-to/ArticleStandard/Article/detail/391532?contextCategoryId=35801&ref=25 The number of biotechnology-based human therapeutic products in the late-stage pipeline, and the average cost to commercialize a biotech product, have steadily increased. This has required biotech companies to use economic analysis as a tool during process development and for making decisions about process design. Process development efforts now aim to create processes that are economical, as well as optimal and robust. 2006-11-01T05:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/502006/391532/TN_thumbnail.jpg http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/502006/391532null XML Disposables: A Solution for Efficient Biopharmaceutical Production http://www.biopharminternational.com/biopharm/Article/Disposables-A-Solution-for-Efficient-Biopharmaceut/ArticleStandard/Article/detail/353133?contextCategoryId=35801&ref=25 Disposables require less space than conventional equipment, and they can be assembled offsite into complete process trains. 2006-07-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/262006/353133null XML The Case for Disposable Manufacturing Equipment to Accelerate Vaccine Development http://www.biopharminternational.com/biopharm/Article/The-Case-for-Disposable-Manufacturing-Equipment-to/ArticleStandard/Article/detail/329361?contextCategoryId=35801&ref=25 Disposables can be used for media preparation, clarification, filling in downstream processes . . . 2006-06-01T04:00:00Z http://www.biopharminternational.com/biopharm/data/articlestandard/biopharm/212006/329361/TN_thumbnail.jpg XML