Promiscuous non-stoichiometric inhibition can be a serious problem when screening libraries of compounds in a high-throughput format. A rapid method of detecting such compound behavior can be achieved using a DynaPro Plate Reader to examine the light scattering properties of a dilution series of known aggregating inhibitors.
Liposomes are made of lipid bilayers and are often used in drug delivery by encapsulating the core with therapeutic drugs. During liposome research, formulation, manufacturing and quality control, it is of great importance to monitor liposome size and encapsulation. Field flow fractionation (FFF) with the concomitant use of Multi-Angle Light Scattering (MALS) and Quasi-Elastic Light Scattering (QELS, aka dynamic light scattering) is an ideal tool for such characterization.