Articles by Leo de Leede - BioPharm International

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Articles by Leo de Leede

Leo de Leede


Leo de Leede is a director of preclinical research and development at OctoPlus NV.

Advances in Single-Shot Vaccine Development
January 2, 2009

The disadvantages of the traditional vaccine regime (prime plus boost) have spurred the development of single-shot vaccines. This article describes the development and manufacture of a prototype single-shot vaccine that uses microspheres made from cross-linked modified dextran polymers for controlled release of the antigen.

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