Manufacturing Process Development for an Epidermal Growth Factor-Based Cancer Vaccine
October 2, 2008
By:
Gryssell Rodriguez
,
Airama Albisa
,
Lisel Viña
,
Ariadna Cuevas
,
Beatriz Garcia
,
Aurora Tamara Garcia
,
Alejandro Portillo
,
Loany Calvo
,
Tania Crombet
,
Gisela Gonzalez
,
Ernesto Chico
The Center for Molecular Immunology (Havana, Cuba) has been working on a novel cancer immunotherapy targeting the epidermal growth factor (EGF). The vaccine is composed of a chemical conjugate of EGF and a carrier protein (rP64k), designed to trigger an anti-EGF antibody response. The results of studies of molecular characterization, immunogenic activity, and clinical data are presented here.
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