Articles by Rick E. Cooley - BioPharm International

ADVERTISEMENT

ADVERTISEMENT

Articles by Rick E. Cooley

Rick E. Cooley


ON-LINE PROCESS CONTROL: Automating the Control of Process-Scale Purification Columns Using On-Line Liquid Chromatography
February 2, 2007

This article discusses how on-line high-performance liquid chromatography (HPLC) can measure product purity in the column eluent stream in near–real time. These data can then enable the automation and control of a purification column operation, thus reducing product variability, shortening process cycle time, and increasing yield. An example application demonstrates how on-line HPLC is used as a process analytical technology to ensure the process can accommodate variability in the separation while ensuring the product meets its critical quality attributes.

ADVERTISEMENT

ADVERTISEMENT

Click here