Articles by Ruta Waghmare - BioPharm International

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Articles by Ruta Waghmare

Ruta Waghmare


Ruta Waghmare is group leader, process development sciences at Millipore Corporation, Billerica, MA 01821.

Articles
Challenges and Strategies for the Downstream Purification and Formulation of Fab Antibody Fragments
January 1, 2014

Antibody fragments pose unique challenges in recovery, purification, and formulation.

Cleaning Polyethersulfone Membranes After Ultrafiltration-Diafiltration in Monoclonal Antibody Production
April 1, 2006

In the pharmaceutical industry, ultrafiltration (UF) membranes are used extensively in the downstream purification of recombinant proteins or monoclonal antibodies. However, the fouling of membranes after a unit operation?especially when recombinant proteins or monoclonal antibodies are highly concentrated?is a common problem. Typically, normalized water permeability (NWP) of a membrane can be reduced to about 20 percent of its original permeability at the end of an ultrafiltration-diafiltration (UF-DF) operation.

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