Articles by Yaling Wu - BioPharm International

ADVERTISEMENT

ADVERTISEMENT

Articles by Yaling Wu

Yaling Wu

Senior Scientist

Yaling Wu is senior scientist in purification sciences department at Human Genome Sciences, Inc.

Cleaning Polyethersulfone Membranes After Ultrafiltration-Diafiltration in Monoclonal Antibody Production
April 1, 2006

In the pharmaceutical industry, ultrafiltration (UF) membranes are used extensively in the downstream purification of recombinant proteins or monoclonal antibodies. However, the fouling of membranes after a unit operation?especially when recombinant proteins or monoclonal antibodies are highly concentrated?is a common problem. Typically, normalized water permeability (NWP) of a membrane can be reduced to about 20 percent of its original permeability at the end of an ultrafiltration-diafiltration (UF-DF) operation.

ADVERTISEMENT

ADVERTISEMENT

Click here