Articles by John Curling - BioPharm International

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Articles by John Curling

Process Chromatography: Five Decades of Innovation

Oct 1, 2007

Low-pressure process chromatography could not have developed without immense efforts to resolve scale-up issues in both column design and matrix stability.

HISTORY OF CHROMATOGRAPHY: Process Chromatography: Five Decades of Innovation

Over the years, chromatography has become the central enabling technology in all biopharmaceutical downstream processing.
Feb 2, 2007

This article explores the development of process chromatography. Process chromatography was first applied to the removal of low molecular weight solutes from whey by gel filtration about 50 years ago. An analytical method using size exclusion chromatography was scaled up for insulin production in the 1970s, when ion exchange became a viable technology for the same application. Ion exchange was adopted as the industry workhorse as robust resins became available and formed the backbone of chromatographic processing of blood plasma fractionation in alternatives to and extensions of ethanol precipitation.

Affinity Chromotography - from Textile Dyes to Synthetic Ligands by Design, Part 2

Sythetic ligand chromatography is set to assume a significant position in the bioseparations armory
Aug 1, 2004

Synthetic ligand adsorbents can eliminate the potential hazards of animal- and microorganism-sourced ligands, minimizing running, cleaning, and validation costs.

Affinity Chromatography — from Textile Dyes to Synthetic Ligands by Design, Part I

Jul 1, 2004

Very significant progress has been made since the mid-1970s when dye ligands were first introduced.

Costing Issues in the Production of Biopharmaceuticals

Manufacturing costs are crucial to overall profit margins.
Feb 1, 2004

Operational planning and early cost analyses are key to generating optimal, robust, and economical commercial processes.

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