Articles by St John Skilton, PhD

Rapid Assessment of Molecular Similarity between a Candidate Biosimilar and an Innovator Monoclonal Antibody Using Complementary LC–MS Methods

Intact protein LC–MS detected a mass variance of 62 Da and peptide mapping located a difference of two amino acids.
Aug 2, 2010
By: Martin Gilar, PhD, Hongwei Xie, PhD, Asish Chakraborty, PhD, Joomi Ahn, Ying Qing Yu, PhD, Weibin Chen, PhD, St John Skilton, PhD, Jeffery R. Mazzeo, PhD, Deepalakshmi P. Dakshinamoorthy

Intact protein LC–MS detected a mass variance of 62 Da and peptide mapping located a difference of two amino acids.

Capturing Conformational Changes in Biotherapeutics by Hydrogen Deuterium Exchange and UHPLC–MS

By providing information on the relative accessibility of locations within a protein, HDX by mass spectrometry opens new windows into the higher order structure of biomolecules.
Aug 2, 2010
By: Joomi Ahn, St John Skilton, PhD

By providing information on the relative accessibility of locations within a protein, HDX by mass spectrometry opens new windows into the higher order structure of biomolecules.