Articles by Tosoh Bioscience - BioPharm International

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Articles by Tosoh Bioscience

TOYOPEARL GigaCap® DEAE-650M Preserving Resolution at Increased Protein Loads

Apr 30, 2013

TOYOPEARL GigaCap DEAE-650M, a very high capacity anion exchange resin for process scale chromatography, offers chromatographers a combination of binding capacities greater than 150 g/L while maintaining peak resolution.

TOYOPEARL GigaCap® DEAE-650M Preserving Resolution at Increased Protein Loads

Mar 26, 2013

TOYOPEARL GigaCap DEAE-650M is an ideal anion exchange resin for the chromatographic purification of biotherapeutic products. Since the TOYOPEARL GigaCap DEAE-650M has such a high dynamic binding capacity, the need for very large columns and massive buffer consumption is minimized, particularly for proteins expressed at higher levels due to upstream improvements.

TOYOPEARL® MX-Trp-650M Salt Selectivity and Tolerance

Feb 26, 2013

TOYOPEARL MX-Trp-650M, a mixed-mode chromatography resin for process scale chromatography, offers chromatographers selectivity and salt tolerance combined with binding capacities that are similar to traditional cation exchange resins.

TOYOPEARL® MX-Trp-650M Resin Selectivity

Jan 30, 2013

TOYOPEARL MX-Trp-650M, a new, mixed-mode chromatography resin combining a weak cation exchange and a hydrophobic ligand is the latest addition to the TOYOPEARL product line.

Purification of mAbs using TOYOPEARL AF-rProtein A-650F

Dec 27, 2012

TOYOPEARL AF-rProtein A-650F was designed for use in mAb purifications. This paper demonstrates the excellent kinetics, superior dynamic binding capacity at very fast flow rates, selectivity and alkaline stability of this resin.

A New Mixed-Mode Resin for Biopurification

Nov 27, 2012

This whitepaper describes TOYOPEARL MX-Trp-650M, a new, mixed mode resin for protein capture. Buffer strengths of 0.20 mol/L NaCl can be used with dynamic binding capacities of up to 90 g/L achieved.

TOYOPEARL® MX-Trp-650M a New Mixed-Mode Resin

Sep 25, 2012

The paper will describe the key performance attributes of TOYOPEARL MX-Trp-650M Mixed-Mode resin and its ability to retain protein capacity even when encountering elevated feedstock or buffer conductivities.

Development of a High Capacity, Mixed-Mode Resin for High Conductivity mAb Feedstocks

Jul 31, 2012

The paper will describe the key performance attributes of TOYOPEARL MX-Trp-650M Mixed-Mode resin and its ability to retain protein capacity even when encountering elevated feedstock or buffer conductivities.

Increased Load of DNA-Based Oligonucleotide on TSKgel SuperQ-5PW (20) Resin

Jun 24, 2011

Oligonucleotides are now entering clinical trials in greater numbers. Their purification requires the use of a high resolution resin to isolate the target from the N-1 and N+1 impurities. This white paper demonstrates the use of TSKgel SuperQ-5PW (20) resin under higher loading conditions, to purify with high yield the target oligonucleotide.

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