Articles by Uwe Gottschalk, PhD - BioPharm International

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Articles by Uwe Gottschalk, PhD

A Renaissance in Biomanufacturing: The Art of Purification

Aug 2, 2013

The industry needs to embrace innovation to improve the efficiency and robustness of biopharmaceutical purification without driving up the cost of goods.

The Future of Downstream Processing-2013

As constant scale up grows out of favor in the biopharmaceutical industry, new—and old—approaches are required.
Aug 2, 2013

As constant scale up grows out of favor in the biopharmaceutical industry, new—and old—approaches are required. The author reviews the state of downstream processing and considers potential solutions, including the streamlining of full processes and borrowed technologies

The Future of Downstream Processing

The author reviews the state of downstream processing, including a look at the streamlining of full processes and borrowed technologies.
Sep 1, 2011

The author reviews the state of downstream processing, including a look at the streamlining of full processes and borrowed technologies.

Innovation and the Art of Downstream Processing

This summary provides an introduction to our special issue on Separation and Purification.
Apr 2, 2011

This summary provides an introduction to our special issue on Separation and Purification.

Technical and Economic Benefits of Membrane Chromatography During Polishing Steps

An analysis of flow rate, load density, viral clearance, footprint, and cost.
Aug 1, 2010

An analysis of flow rate, load density, viral clearance, and cost.

Antibody Purification Using Membrane Adsorbers

A membrane adsorber in retention mode can be used efficiently in a commercial antibody manufacturing process.
Oct 2, 2009

A membrane adsorber in retention mode can be used efficiently in a commercial antibody manufacturing process.

Salt Tolerant Interaction Chromatography for Large-Scale Polishing with Convective Media

STIC allows polishing to be carried out without an interstitial dilution step, which reduces process time and avoids additional buffer preparation and hold steps.
Oct 2, 2009

STIC allows polishing to be carried out without an interstitial dilution step, which reduces process time and avoids additional buffer preparation and hold steps.

Antibody Purification Using Membrane Adsorbers

Results from a process developed for a commercial antibody.
Dec 1, 2008

Results from a process developed for a commercial antibody.

Disposable Decisions

To achieve the right balance between disposable and reuseable options, companies must consider important technical and economic factors.
Oct 1, 2008

To achieve the right balance between disposable and reuseable options, companies must consider important technical and economic factors.

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