Articles by Ruta Waghmare - BioPharm International

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Articles by Ruta Waghmare

Challenges and Strategies for the Downstream Purification and Formulation of Fab Antibody Fragments

The authors outline some of the unique requirements and challenges posed by antibody fragments in terms of recovery, purification, and formulation.
Jan 1, 2014

Antibody fragments pose unique challenges in recovery, purification, and formulation.

Cleaning Polyethersulfone Membranes After Ultrafiltration-Diafiltration in Monoclonal Antibody Production

Polyethersulfone membranes can be cleaned safely, effectively, and economically.
Apr 1, 2006

In the pharmaceutical industry, ultrafiltration (UF) membranes are used extensively in the downstream purification of recombinant proteins or monoclonal antibodies. However, the fouling of membranes after a unit operation?especially when recombinant proteins or monoclonal antibodies are highly concentrated?is a common problem. Typically, normalized water permeability (NWP) of a membrane can be reduced to about 20 percent of its original permeability at the end of an ultrafiltration-diafiltration (UF-DF) operation.

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