Articles by Yaling Wu - BioPharm International

ADVERTISEMENT

ADVERTISEMENT

Articles by Yaling Wu

Cleaning Polyethersulfone Membranes After Ultrafiltration-Diafiltration in Monoclonal Antibody Production

Polyethersulfone membranes can be cleaned safely, effectively, and economically.
Apr 1, 2006

In the pharmaceutical industry, ultrafiltration (UF) membranes are used extensively in the downstream purification of recombinant proteins or monoclonal antibodies. However, the fouling of membranes after a unit operation?especially when recombinant proteins or monoclonal antibodies are highly concentrated?is a common problem. Typically, normalized water permeability (NWP) of a membrane can be reduced to about 20 percent of its original permeability at the end of an ultrafiltration-diafiltration (UF-DF) operation.

ADVERTISEMENT

ADVERTISEMENT

Click here