An Environmental Life Cycle Assessment Comparing Single-Use and Conventional Process Technology - The authors compare the environmental impact of monoclonal antibody production using fixed-in-place pr


An Environmental Life Cycle Assessment Comparing Single-Use and Conventional Process Technology
The authors compare the environmental impact of monoclonal antibody production using fixed-in-place processing and single-use systems.

BioPharm International Supplements
pp. s30-s38


The study has shown that a shift from traditional durable process technology to single-use process technology can result in substantial reductions in cumulative energy demand, global warming potential, and water usage for the production of monoclonal antibodies, in addition to improving flexibility and productivity. Although single-use process technology introduces a need for the production, distribution, and disposal of single-use components, this approach also reduces or eliminates the need for large quantities of steam, process water, and water for injection. The LCA model developed for this study is dynamic and offers the potential for further exploration of different bioprocess conditions and "what if" scenarios. The detailed insights gained in this comprehensive study offer the potential for further improvements in environmentally conscious product and process development for biopharmaceutical manufacturing.

Matthew Pietrzykowski is a research chemist, and William Flanagan* is the leader, both at at the Ecoassessment Center of Excellence, GE Global Research, Niskayuna, NY. Vincent Pizzi is a global product marketing leader at GE Healthcare, Westborough, MA. Andrew Brown is a bioprocess engineer, Andrew Sinclair is managing director, and Miriam Monge is vice-president, all at Biopharm Services Ltd., Chesham, UK. *


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10. Dr. Pascal Lesage (researcher, CIRAIG), Dr. Dirk Böhm (director, large-scale biotech operations, Merck Serono), Ekta Mahajan (senior engineer, Genentech Inc.)

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