The Future of Downstream Processing - The author reviews the state of downstream processing, including a look at the streamlining of full processes and borrowed technologies. - BioPharm International

ADVERTISEMENT

The Future of Downstream Processing
The author reviews the state of downstream processing, including a look at the streamlining of full processes and borrowed technologies.


BioPharm International
Volume 24, Issue 9, pp. 38-47

REFERENCES

1. U. Gottschalk, Biopharm. Int. 19, s8–s9 (2006).

2. D.L. Hacker, M. De Jesus, and F.M. Wurm, Biotechnol. Adv. 27, 1023–1027 (2009).

3. A.S. Rathore and H. Winkle, Nat. Biotechnol. 27, 26–34 (2009).

4. W. Berthold, Proceedings of BioManufacturing World 2010 (Shanghai, China, 2010).

5. F.M. Wurm, Nature 22, 1393–1398 (2004).

6. S. Aldridge, GEN, 26 (1) (2006).

7. FDA, Pharmaceutical cGMPs for the 21st Century: A Risk-Based Approach (Rockville, MD, August 2002).

8. FDA, PAT Guidance for Industry: A Framework for Innovative Pharmaceutical Development, Manufacturing, and Quality Assurance (Rockville, MD, September 2004).

9. K.A. Thiel, Nat. Biotechnol 22, 1365–1372 (2004).

10. C. Sheridan, Nat. Biotechnol. 28, 307–310 (2010).

11. G. Walsh, Nat. Biotechnol. 28, 917–924 (2010).

12. U. Gottschalk, BioPharm. Int. 18 (3), s24–s28 (2005).

13. S. Vunnum, G. Vedantham, and B. Hubbard "Protein A-based Affinity Chromatography," in Process Scale Purification of Antibodies, U. Gottschalk, Ed. (Wiley, NY, 2009), pp. 79–102.

14. J. Glynn et al., "The Development and Application of a Monoclonal Antibody Purification Platform," supplement to Biopharm. Int. (2009).

15. J. Glynn et al., "Development of a MAb Harvest Protocol", proceedings of Biochemical Engineering XV: Engineering Biology from Biomolecules to Complex Systems (Quebec City, Canada, 2007) pp 15–19.

16. J. Thömmes and M. Etzel, Biotechnol. Prog. 23, 42–45 (2007).

17. J. Thömmes and U. Gottschalk, "Alternatives to Packed-bed Chromatography for Antibody Extraction and Purification," in Process-scale Purification of Antibodies, U. Gottschalk, Ed. (Wiley, NY, 2009) pp. 293–308.

18. A.A. Shulka and J.R. Kandula, "Harvest and recovery of monoclonal antibodies: Cell Removal and Clarification" in Process-scale Purification of Antibodies, U. Gottschalk, Ed. (Wiley, NY 2009) pp. 53–78.

19. R. Shpritzer et al., presentation at 232nd ACS National Meeting (San Francisco CA, 2006).

20. J. Glynn, "Process Scale Precipitation of Impurities in Mammalian Cell Culture Broth," in Process-scale Purification of Antibodies, U. Gottschalk, Ed. (Wiley, NY, 2009) pp. 309–324.


blog comments powered by Disqus

ADVERTISEMENT

ADVERTISEMENT

FDA Approves Pfizer's Trumenba for the Prevention of Meningitis B
October 30, 2014
EMA: Extrapolation Across Indications for Biosimilars a Possibility
October 30, 2014
Bristol-Myers Squibb Announces Agreement to Acquire HER2-Targeted Cancer Treatment
October 29, 2014
Contract Research and Manufacturing Organization Paragon Bioservices Raises $13 Million
October 28, 2014
Yale and Gilead Extend Sequencing Initiative
October 28, 2014
Author Guidelines
Source: BioPharm International,
Click here