Industrialized Production of Human iPSC-Derived Cardiomyocytes for Use in Drug Discovery and Toxicity Testing - The authors describe an industrialized process for the manufacture of iPSC-derived human

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Industrialized Production of Human iPSC-Derived Cardiomyocytes for Use in Drug Discovery and Toxicity Testing
The authors describe an industrialized process for the manufacture of iPSC-derived human cardiomyocytes.


BioPharm International
Volume 24, Issue 3, pp. 58-67

CONCLUSION

Cellular Dynamics (Madison, WI) has developed a highly standardized, scalable process to manufacture human iPSC-derived cardiomyocytes. Using this process, the company launched its iCell Cardiomyocytes product line in December 2009, whereby we can produce the hundreds of billions of human cardiomyocytes needed by the pharmaceutical industry for drug-toxicity testing.

These iCell Cardiomyocytes demonstrate molecular and physiological properties and show sensitivity to cardiotoxic compounds expected of human cardiomyocytes. The ability to consistently produce large numbers of high quality and high purity cardiomyocytes offers the pharmaceutical industry a new tool to better predict the cardiotoxicity of new drug candidates. It is expected that these cells will allow pharmaceutical companies to more efficiently select drug candidates while reducing the likelihood that cardiotoxic activity of these compounds will manifest themselves late in development or after regulatory approval and market launch.

Blake Anson* is iCell Cardiomyocyte product manager, Emile Nuwaysir is COO, Brad Swanson is director of cell biology product development, and Wen Bo Wang is director of process sciences, all at Cellular Dynamics International, 525 Science Drive, Madison, WI 53711.

*To whom all correspondence should be addressed.

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