CONCLUSIONS
The methods in this article illustrate how process scheduling and debottlenecking can result in process intensification, thus
reducing batch time, increasing plant productivity and, ultimately, decreasing the cost of manufacturing. The first case study
focused on the procedure for scheduling a biotech process, debottlenecking, economical and optimal scale-up, developing a
buffer preparation model, and optimizing the number of buffer and media preparation and hold-up tanks. The second case study
demonstrated the development of a model for buffer preparation and the optimization of the total number of tanks required
for a multiproduct biotech facility.
Anurag S. Rathore is a biotech CMC consultant and a faculty member, and Tarun Sengar is a student in the department of chemical engineering, both at the Indian Institute of Technology, Delhi, India, +91 9650770650,
asrathore@biotechcmz.com
. Rathore is also a member of the BioPharm International editorial advisory board.
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