Characterization of Aluminum Hydroxide Gel and Oil-in-Water Emulsion Formulations Containing CpG ODNs - Adjuvant activity can be greatly improved by appropriate formulation of cytosine

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Characterization of Aluminum Hydroxide Gel and Oil-in-Water Emulsion Formulations Containing CpG ODNs
Adjuvant activity can be greatly improved by appropriate formulation of cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs).


BioPharm International Supplements


Acknowledgments

This work was supported in part by Grant 42387 from the Bill & Melinda Gates Foundation. The authors would like to thank Martin Freide, PhD, for helpful discussions regarding method development.

CHRISTOPHER B. FOX is the lead formulation engineer, TIMOTHY S. DUTILL is the process development specialist II, JAMES CHESKO is a senior scientist, STEVE G. REED is the head of research and development, and THOMAS S. VEDVICK is the director of process sciences, all at the Infections Disease Research Institute, Seattle, WA, 206.330.2527,
RYAN C. ANDERSON, formerly of the Infections Disease Research Institute, currently is the account consultant—northern California, at Chemical Abstracts Service, Columbus, OH.

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