Capturing Conformational Changes in Biotherapeutics by Hydrogen Deuterium Exchange and UHPLC–MS - By providing information on the relative accessibility of locations within a protein, HDX by

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Capturing Conformational Changes in Biotherapeutics by Hydrogen Deuterium Exchange and UHPLC–MS
By providing information on the relative accessibility of locations within a protein, HDX by mass spectrometry opens new windows into the higher order structure of biomolecules.


BioPharm International Supplements


References

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6. Laboratory of Molecular Structure Characterization [homepage on the Internet]. Draw map for peptic peptide coverage map. Prague, Czech Republic: Institute of Microbiology; [cited 2010 July 9]. Available from: http://ms.biomed.cas.cz/MSTools/.

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8. Iacob RE, Murphy III JP, Engen JR. Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange. Rapid Commun Mass Spec. 2008;22:2898–904; DOI: 10.1002/rcm.3688.

9. Rand KD, Pringle SD, Murphy III JP, Fadgen KE, Brown J, Engen JR. Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations. Anal Chem. 2009;81:10019–28.

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