Applying Computational Fluid Dynamics Technology in Bioprocesses-Part 2 - Computational fluid dynamics can resolve performance problems. - BioPharm International

ADVERTISEMENT

Applying Computational Fluid Dynamics Technology in Bioprocesses-Part 2
Computational fluid dynamics can resolve performance problems.


BioPharm International
Volume 23, Issue 5

76. Bavarian F, Fan LS, Chalmers JJ. Microscopic visualization of insect cell-bubble interactions. I: Rising bubbles, air-medium interface, and the foam layer. Biotechnol Prog. 1991;7(2):140–50.

77. Chalmers JJ, Bavarian F. Microscopic visualization of insect cell-bubble interactions. II: The bubble film and bubble rupture. Biotechnol Prog. 1991;7(2):151–8.

78. Orton DR, Wang DIC. Fluorescent visualization of cell death in bubble aerated bioreactors: Cell Culture Engineering III. Chem Eng Comm. 1992:118(1):341–60.

79. Trinh K, Garcia-Briones M, Chalmers JJ, Hink F. Quantification of damage to suspended insect cells as a result of bubble rupture. Biotech Bioeng. 1994;43(1):37–45.

80. Handa A, Emery AN, Spier R. On the evaluation of gas-liquid interfacial effects on hybridoma viability in bubble column bioreactors. Dev Biol Stand. 1987;66:241–53.

81. Kunas KT, Papoutsakis ET. Damage mechanisms of suspended animal cells in agitated bioreactors with and without bubble entrainment. Biotech Bioeng. 2009;102(4):977–87.

82. Boulton-Stone JM, Blake JR. Gas bubbles bursting at a free surface. J Fluid Mech. 1993;254:437–66.

83. Garcia-Briones M, Brodkey R, Chalmers JJ. Computer simulations of the rupture of a gas bubble at a gas-liquid interface and its implications in animal cell damage. Chem Eng Sci. 1994;49(14):2304–20.

84. Mollet M, Ma N, Zhao Y, Brodkey R, Taticek R, Chalmers JJ. Bioprocess equipment: characterization of energy dissipation rate and its potential to damage cells. Biotechnol Prog. 2004;20(5):1437–48.

85. Elias CB, Desai RB, Patole MS, Joshi JB, Mashelkar RA. Turbulent shear stress—effect on mammalian cell culture and measurement using laser Doppler anemometer. Chem Eng Sci. 1995;50(15):2431–40.

86. Miller J, Rogowski M, Kelly W. Using a CFD model to understand the fluid dynamics promoting E. coli breakage in a high-pressure homogenizer. Biotechnol Prog. 2002;18(5):1060–7.

87. Fang Z. Use of CFD to troubleshoot cell culture performance in production scale bioreactors during technology transfer, AIChE annual meeting; 2008; Philadelphia, PA.

88. Fang Z, Nyberg G, Hunt S, Crowell C, Gall S, Fan M. Use of CFD to identify and resolve the root causes for abnormal cell culture performance observed at large-scale during technology transfer. Biotech Bioeng. 2009 (to be submitted).


blog comments powered by Disqus

ADVERTISEMENT

ADVERTISEMENT

NIH Launches Human Safety Study of Ebola Vaccine Candidate
August 29, 2014
Suppliers Seek to Boost Single-Use Technology
August 21, 2014
Bristol-Myers Squibb and Celgene Collaborate on Immunotherapy and Chemotherapy Combination Regimen
August 20, 2014
FDA Warns about Fraudulent Ebola Treatments
August 15, 2014
USP Awards Analytical Research
August 15, 2014
Author Guidelines
Source: BioPharm International,
Click here