Applying Computational Fluid Dynamics Technology in Bioprocesses-Part 2 - Computational fluid dynamics can resolve performance problems. - BioPharm International

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Applying Computational Fluid Dynamics Technology in Bioprocesses-Part 2
Computational fluid dynamics can resolve performance problems.


BioPharm International
Volume 23, Issue 5

56. Hristov HV, Mann R, Lossev V, Vlaev SD, Seichter P. A 3-D analysis of gas-liquid mixng, mass transfer and bioreaction in a stirred bioreactor. Trans Inst Chem Eng. 2001;79:232–41.

57. Xu B, Jahic M, Enfors SO. Modelling of overflow metabolism in batch and fed-batch cultures of Escherichia coli. Biotechnol Prog. 1999;15:81–90.

58. Smith MW, Neeidhardt FC. Proteins induced by anaerobiosis in Escherichia coli. J Bacteriol. 1983;154:336–43.

59. Dhanasekharan KM, Sanyal J, Jain A, Haidari A. A generalized approach to model oxygen transfer in bioreactors using population balances and computational fluid dynamics. Chem Eng Sci. 2005;60(1):213–8.

60. Bajpai PK, Reuss M. Coupling of mixing and microbial kinetics for evaluating the performance of bioreactors. Can J Chem Eng. 1982;60:384–92.

61. Reuss M, Schmalzriedt S, Jenne M. Application of computational fluid dynamics (CFD) to modeling stirred-tank bioreactors. In: Schugerl K, Bellgardt KH, editors. Bioreaction Engineering Modeling and Control. Berlin: Springer; 2000.

62. Larsson G, Törnkvist M, Wernersson ES, Trägårdh C, Noorman H, Enfors SO. Substrate gradients in bioreactors: origin and consequences. Bioproc Biosys Eng. 1996;14(6):281–9.

63. Ma N, Mollet M, Chalmers JJ. Aeration, mixing and hydrodynamics in bioreactors. In: Ozturk SS, Hu WS, editor. Cell culture technology for pharmaceutical and cell-based therapies. New York, London: 2006; Taylor & Francis.

64. Wu J. Mechanisms of animal cell damage associated with gas bubbles and cell protection by medium additives. J Biotechnol. 1995;43(2):81–94.

65. Chisti Y. Animal-cell damage in sparged bioreactors. Trends in biotechnology. 2000 Oct 18;(10):420–32.

66. Jöbses I, Martens D, Tramper J. Lethal events during gas sparging in animal cell culture. Biotech Bioeng. 1991;37(5):484–90.

67. Murhammer DW, Goochee CF. Sparged animal cell bioreactors: mechanism of cell damage and Pluronic F-68 protection. Biotechnol Prog. 1990;6(5):391–7.

68. Garcia-Briones M, Chalmers JJ. Cell-bubble interactions. Mechanisms of suspended cell damage. Ann New York Acad Sci. 1992;665:219–29.

69. Chattopadhyay D, Rathman JF, Chalmers JJ. The protective effect of specific medium additives with respect to bubble rupture. Biotech Bioeng. 1995;45(6):473–80.

70. Meier SJ, Hatton A, Wang DI. Cell death from bursting bubbles: Role of cell attachment to rising bubbles in sparged reactors. Biotech Bioeng. 1998;62(4):468–78.

71. Koynov A, Tryggvason G, Khinast JG. Characterization of the localized hydrodynamic shear forces and dissolved oxygen distribution in sparged bioreactors. Biotech Bioeng. 2007;97(2):317–31.

72. Schaffer M, Yianneskis M, Wachter P, Durst F. Trailing vortices around a 45° pitched-blade impeller. AIChE J. 1998;44(5):1233–46.

73. Maa Y-F, Hsu CC. Effect of high shear on proteins. Biotech Bioeng. 1996;51(4):458–65.

74. Maa Y-F, Hsu CC. Protein denaturation by combined effect of shear and air-liquid interface. Biotech Bioeng. 1997;54(6):503–12.

75. Kioukia N, Nienow AW, Emery AN, Al-Rubeai M. The impact of fluid dynamics on the biological performance of free suspension animal cell culture: Further studies. Trans Inst Chem Eng Part C. 1992;70:143–7.


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