Applying Computational Fluid Dynamics Technology in Bioprocesses-Part 2 - Computational fluid dynamics can resolve performance problems. - BioPharm International


Applying Computational Fluid Dynamics Technology in Bioprocesses-Part 2
Computational fluid dynamics can resolve performance problems.

BioPharm International
Volume 23, Issue 5

37. Jenne M, Reuss M. Fluid dynamic modeling and simulation of gas-liquid flow in baffled stirred-tank reactors. Ninth European conference on mixing; 1997; Paris. p. 201–08.

38. Jaworski Z, Bujalski W, Otomo N, Nienow AW. CFD study of homogenization with dual Rushton turbines-comparison with experimental results. Part I: Initial studies. Chem Eng Res Des. 2000;78(3):327–33.

39. Montante G, Mostek M, Johoda M, Magelli F. CFD simulations and experimental validation of homogenisation curves and mixing time in stirred Newtonian and pseudoplastic liquids. Chem Eng Sci. 2005;60:2427–37.

40. Derksen JJ. Numerical simulation of solids suspension in a stirred-tank. AIChE J. 2003;49(11):2700–14.

41. Kraume M. Mixing times in stirred suspensions. Chem Eng Tech. 1992;15(5):313–8.

42. Derksen JJ. Long-time solids suspension simulations by means of a large-eddy approach. Chem Eng Res Des. 2006;84(1):38–46.

43. Barrue H, Bertrand J, Cristol B, Xuereb C. Eulerian simulation of dense solid-liquid suspension in multi-stage stirred vessel. J Chem Eng Jpn. 1999;34:585–94.

44. Micale G, Montante G, Grisafi F, Brucato A, Godfrey J. CFD simulation of particle distribution in stirred reactors. Trans Inst Chem Eng Part A. 2000;78:435–444.

45. Murthy BN, Joshi JB. Assessment of standard k-(epsilon), RSM and LES turbulence models in a baffled stirred vessel agitated by various impeller designs. Chem Eng Sci. 2008;63(22):5468–95.

46. Khopkar AR, Tanguy PA. CFD simulation of gas-liquid flows in stirred vessel equipped with dual Rushton turbines: influence of parallel, merging and diverging flow configurations. Chem Eng Sci. 2008;63(14):3810–20.

47. Jahoda M, Mostek M, Kukukova A, Machon V. CFD modelling of liquid homogenization in stirred-tanks with one and two impellers using large eddy simulation. Chem Eng Res Des. 2007;85(5A):616–25.

48. Kumar S, Ramkrishna D. On the solution of population balance equations by discretization—III. Nucleation, growth and aggregation of particles. Chem Eng Sci. 1997;52(24):4659–79.

49. L. Marchisio D, Dennis Vigil R, O. Fox R. Implementation of the quadrature method of moments in CFD codes for aggregation-breakage problems. Chem Eng Sci. 2003;58(15):3337–51.

50. Cheung SCP, Yeoh GH, Tu JY. On the modeling of population balance in isothermal vertical bubbly flows—Average bubble number density approach. Chem Eng Proc: Proc Intens. 2007;46(8):742–56.

51. Bakker A, Van den Akker HEA. Computational model for the gas-liquid flow in stirred reactors. Chem Eng Res Des. 1994;72(A4):594–606.

52. Tatterson GB. Fluid mixing and gas dispersion in agitated tanks. New York: Mcgraw-Hill; 1991.

53. Montante G, Micale G, Magelli F, Brucato A. Experiments and CFD predictions of solid particle distribution in a vessel agitated with four pitched blade turbines. Chem Eng Res Des. 2001;79:1005–10.

54. Nienow AW, Hunt G, Buckland BC. A fluid dynamic study of the retrofitting of large agitated bioreactors: Turbulent flow. Biotech Bioeng. 1994;44(10):1177–85.

55. Bylund F, Collet E, Enfors SO, Larsson G. Substrate gradient formation in the large-scale bioreactor lowers cell yield and increases by-product formation. Bioproc Biosys Eng. 1998;18(3):171–80.

blog comments powered by Disqus



AbbVie/Shire Deal Officially Off
October 20, 2014
Amgen Sues Sanofi and Regeneron over Patent for mAb Targeting PCSK9
October 20, 2014
EMA Works to Speed Up Ebola Treatment
October 20, 2014
Lilly to Close Manufacturing Facility in Puerto Rico
October 17, 2014
BioReliance Introduces New Predictive Assays
October 17, 2014
Author Guidelines
Source: BioPharm International,
Click here