Applying Computational Fluid Dynamics Technology in Bioprocesses-Part 2 - Computational fluid dynamics can resolve performance problems. - BioPharm International


Applying Computational Fluid Dynamics Technology in Bioprocesses-Part 2
Computational fluid dynamics can resolve performance problems.

BioPharm International
Volume 23, Issue 5


1. Ketterhagen Wr, Am Ende MT, Hancock BC. Process modeling in the pharmaceutical industry using the Discrete Element method. J Pharma Sci. 2008;98(2):442–67.

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3. Bakker A, Van den Akker HEA. Single phase flow in stirred reactors. Chem Eng Res Des. 1998;72:583–93.

4. Derksen J, Harry J, Van den Akker EA. Large eddy simulations on the flow driven by a Rushton turbine. AIChE J. 1999;45(2):209–21.

5. Delafosse A, Line A, Morchain J, Guiraud P. LES and URANS simulations of hydrodynamics in mixing tank: Comparison to PIV experiments. Chem Eng Res Des. 2008;86(12):1322–30.

6. Bakker A, Oshinowo LM. Modeling of turbulence in stirred vessels using large eddy simulation. Chem Eng Res Des. 2004;82(9):1169–78.

7. Ranade VV, Perrard M, Le Sauze N, Xuereb C, Bertrand J. Trailing vortices of Rushton turbine: PIV measurements and CFD simulations with snapshot approach. Chem Eng Res Des. 2001;79(1):3–12.

8. Ranade VV, Perrard M, Xuereb C, Le Sauze N, Bertrand J. Influence of gas flow rate on the structure of trailing vortices of a Rushton turbine: PIV measurements and CFD simulations. Chem Eng Res Des. 2001;79(8):957–64.

9. Dakshinamoorthy D, Khopkar AR, Louvar JF, Ranade VV. CFD simulations to study shortstopping runaway reactions in a stirred vessel. J Loss Prev Proc Ind. 2004;17(5):355–64.

10. Khopkar AR, Tanguy PA. CFD simulation of gas-liquid flows in stirred vessel equipped with dual Rushton turbines: influence of parallel, merging and diverging flow configurations. Chem Eng Sci. 2008;63(14):3810–20.

11. Galletti C, Brunazzi E. On the main flow features and instabilities in an unbaffled vessel agitated with an eccentrically located impeller. Chem Eng Sci. 2008;63(18):4494–505.

12. Galletti C, Paglianti A, Yianneskis M. Observations on the significance of instabilities turbulence and intermittent motions on fluid mixing processes in stirred reactors. Chem Eng Sci. 2005;60(8–9):2317–31.

13. Myers KJ, Bakker A. A digital particle image velocimetry investigation of flow field instabilities of axial-flow impellers. J Fluids Eng. 1997;119(3):623–33.

14. Montes JL, Boisson H-C, Fort I, Jahoda M. Velocity field macro-instabilities in an axially agitated mixing vessel. Chem Eng J. 1997;67(2):139–45.

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17. Nikiforakia L, Montanteb G, Leea KC, Yianneskisa M. On the origin, frequency and magnitude of macro-instabilities of the flows in stirred vessels. Chem Eng Sci. 2003;58:2937–49.

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