Applying Computational Fluid Dynamics Technology in Bioprocesses-Part 2 - Computational fluid dynamics can resolve performance problems. - BioPharm International


Applying Computational Fluid Dynamics Technology in Bioprocesses-Part 2
Computational fluid dynamics can resolve performance problems.

BioPharm International
Volume 23, Issue 5


1. Ketterhagen Wr, Am Ende MT, Hancock BC. Process modeling in the pharmaceutical industry using the Discrete Element method. J Pharma Sci. 2008;98(2):442–67.

2. Langrish TAG. Multi-scale mathematical modelling of spray dryers. J Food Eng. 2009;93(2):218–28.

3. Bakker A, Van den Akker HEA. Single phase flow in stirred reactors. Chem Eng Res Des. 1998;72:583–93.

4. Derksen J, Harry J, Van den Akker EA. Large eddy simulations on the flow driven by a Rushton turbine. AIChE J. 1999;45(2):209–21.

5. Delafosse A, Line A, Morchain J, Guiraud P. LES and URANS simulations of hydrodynamics in mixing tank: Comparison to PIV experiments. Chem Eng Res Des. 2008;86(12):1322–30.

6. Bakker A, Oshinowo LM. Modeling of turbulence in stirred vessels using large eddy simulation. Chem Eng Res Des. 2004;82(9):1169–78.

7. Ranade VV, Perrard M, Le Sauze N, Xuereb C, Bertrand J. Trailing vortices of Rushton turbine: PIV measurements and CFD simulations with snapshot approach. Chem Eng Res Des. 2001;79(1):3–12.

8. Ranade VV, Perrard M, Xuereb C, Le Sauze N, Bertrand J. Influence of gas flow rate on the structure of trailing vortices of a Rushton turbine: PIV measurements and CFD simulations. Chem Eng Res Des. 2001;79(8):957–64.

9. Dakshinamoorthy D, Khopkar AR, Louvar JF, Ranade VV. CFD simulations to study shortstopping runaway reactions in a stirred vessel. J Loss Prev Proc Ind. 2004;17(5):355–64.

10. Khopkar AR, Tanguy PA. CFD simulation of gas-liquid flows in stirred vessel equipped with dual Rushton turbines: influence of parallel, merging and diverging flow configurations. Chem Eng Sci. 2008;63(14):3810–20.

11. Galletti C, Brunazzi E. On the main flow features and instabilities in an unbaffled vessel agitated with an eccentrically located impeller. Chem Eng Sci. 2008;63(18):4494–505.

12. Galletti C, Paglianti A, Yianneskis M. Observations on the significance of instabilities turbulence and intermittent motions on fluid mixing processes in stirred reactors. Chem Eng Sci. 2005;60(8–9):2317–31.

13. Myers KJ, Bakker A. A digital particle image velocimetry investigation of flow field instabilities of axial-flow impellers. J Fluids Eng. 1997;119(3):623–33.

14. Montes JL, Boisson H-C, Fort I, Jahoda M. Velocity field macro-instabilities in an axially agitated mixing vessel. Chem Eng J. 1997;67(2):139–45.

15. Hasal P, Montes J-L, Boisson H-C, Fort I. Macro-instabilities of velocity field in stirred vessel: detection and analysis. Chem Eng Sci. 2000;55(2):391–401.

16. Roussinova V, Kresta SM, Weetman R. Low frequency macrostabilities in a stirred-tank: scale-up and prediction based on large eddy simulations. Chem Eng Sci. 2003;58:2297–311.

17. Nikiforakia L, Montanteb G, Leea KC, Yianneskisa M. On the origin, frequency and magnitude of macro-instabilities of the flows in stirred vessels. Chem Eng Sci. 2003;58:2937–49.

blog comments powered by Disqus



New Tax Rules May Deter Future Pharma M&A
October 1, 2014
NIH Seeks to Improve Vaccine Response with New Adjuvants
September 30, 2014
New Report Details Players and Pipelines in the Biosimilar Space
September 30, 2014
Baxter International Plans to Open R&D Center for Baxalta
September 30, 2014
FDA Releases First-Ever Purple Book for Biosimilar Characterization
September 26, 2014
Author Guidelines
Source: BioPharm International,
Click here