Advances in Monoclonal Antibody Purification - New technologies and adaptations of existing technologies can improve platform processes. - BioPharm International

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Advances in Monoclonal Antibody Purification
New technologies and adaptations of existing technologies can improve platform processes.


BioPharm International Supplements


References

1. Cordoba-Rodriguez RV. Aggregates in MAbs and recombinant therapeutic proteins: a regulatory perspective. BioPharm Int 2008;21(11):44–53.

2. Fahrner RL, Knudsen HL, Basey CD, Galan W, Feuerhelm D, Vanderlaan M, et al. Industrial purification of pharmaceutical antibodies: development, operation, and validation of chromatography processes. Biotechnol Genet Eng Rev. 2001;18:301–27.

3. Kelley B. Very large scale monoclonal antibody purification: the case for conventional unit operations. Biotechnol Progr. 2007;23(5):995–1008.

4. Walsh G. Biopharmaceutical benchmarks 2006. Nat Biotechnol. 2006;24(7):769–76.

5. Low D, O'Leary R. Pujar NS. Future of antibody purification. J Chrom B, 2007;848(1):48–63.

6. Farid, S. Process economic drivers in industrial monoclonal antibody manufacture. In: Gottschalk U, editor. Process scale purification of antibodies. Hoboken, NJ: John Wiley & Sons; 2009. p. 239–62.

7. Zhou JX, Tressel T. Basic concepts in Q membrane chromatography for large-scale antibody production. Biotechnol Prog. 2006;22(2):341–9.

8. Boi C. Membrane adsorbers as purification tools for monoclonal antibody purification. J Chrom B. 2007;848(1):19–27.

9. Gottschlich N, Kasche V. Purification of monoclonal antibodies by simulated moving-bed chromatography. J Chrom A. 1997;765(2):201–6.

10. Strohlein G, Aumann L, Muller-Spath T. Morbidelli M. The multicolumn countercurrent solvent fradient purification process. BioPharm Int. 2007 Feb supplement, Advances in Process Chromatography;42–8.

11. Muller-Spath T, Aumann L, Strohlein G. Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP). Biotechnol Bioeng. 2008;100(6):1166–77.

12. Przybycien TM, Pujar NS, Steele LM. Alternative bioseparation operations: life beyond packed-bed chromatography. Curr Opin Biotech. 2004;15(5):469–78.

13. McDonald P, Victa C, Carter-Franklin JN, Fahrner R. Selective antibody precipitation using polyelectrolytes: A novel approach to the purification of monoclonal antibodies Biotech Bioeng. 2009;102(4):1141–51.

14. Giese, G. Polyethylene glycol precipitation of monoclonal antibodies and the impact on column chromatography. Presented at BioProcess International Conference 2009.

15. Glynn, J. Process-scale precipitation of impurities in mammalian cell culture broth. In: Gottschalk U, editor. Process scale purification of antibodies. Hoboken, NJ: John Wiley & Sons; 2009. p. 309–24.

16. Wang J, Diehl T, Aguiar D, Dai XP, Arunakumari A. BioPharm Int. 2009 Jan Supplement, Vaccine Development and Manufacturing: Pandemics and Beyond;22(10):4–10.


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