Bioterminology - - BioPharm International

ADVERTISEMENT

Bioterminology

BioPharm International Supplements


hemoglobin A complex protein (a 4-mer) in red blood cells that binds and releases oxygen, carrying it from the lungs to all other tissues.

HEPA filtration High-efficiency particulate air filter used to remove contaminants or to prevent particles from entering a clean room.

heterogeneity A term used to describe a biological component (i.e. protein) consisting of multiple structural variations.

HCH Human growth hormone; an early biopharmaceutical. Formerly derived from cadaveric pituitary glands, this protein is now produced by recombinant expression.

HIC Hydrophobic interaction chroma-tography; a type of liquid chromatography that makes use of the relative solubility of proteins and matrix materials. Hydrophobic interactions are strongest at high ionic strengths, so salt is usually included to increase those levels.

high-throughput screening Robotic methods used to sort through thousands of chemical compounds by running assays on many at a time.

His Histidine; one of more than 20 naturally occurring amino acids.

histochemistry A science that combines the techniques of biochemistry and histology to deal with the chemical changes and chemical constitution of tissues.

hit In drug discovery, a positive result in a high-throughput assay.

hormone A protein released by endocrine glands or sex organs to travel in the blood and act on tissues at another location in the body.

host A cell or organism used for growth of a virus, plasmid, or for the production of cloned substances.

host cell protein(s) (HCP) Proteins from the host cell system used to manufacture a biopharmaceutical drug. Host cells contain hundreds to thousands of host cell proteins and other biomolecules that could contaminate the final product.

HPLC High-performance liquid chromatography or high-pressure liquid chromatography; a form of liquid chromatography in which a sample is forced at high pressure through a tube (column) that is packed tightly with chromatographic media.


High Definition Mass Spectrometry, is possible with the Waters SYNAPTTM G2 HDMS System. It combines high efficiency ion mobility-based measurements and separations with quadrupole time-of flight (TOF) mass spectrometry, enabling researchers to differentiate samples by size, shape, charge, and mass.
human genome The complete set of human genetic instructions.

hybridization The process of joining complementary strands of DNA to make an RNA-DNA hybrid; the partial pairing of DNA single strands from genetically different sources.

hybridoma An immortalized cell line (usually derived by fusing B-lymphocyte cells with myeloma tumor cells) that secretes desirable antibodies.

hydrolysis Literally "cleaved by water," a reaction in which the chemical bond attaching an atom or group of atoms to the rest of a molecule is severed, followed by attachment of hydrogen at the same point. Most often in biopharmaceuticals, the breakage of peptide bonds by addition of a water molecule.

hydrophilic Having an affinity for water; attracting, dissolving in, or absorbing water; readily absorbing moisture; having strongly polar molecular groups that readily interact with water.

hydrophobic Insoluble in water; the extent of insolubility; not readily absorbing water; resisting or repelling water, wetting, or hydra-tion; or being adversely affected by water.

hydrophobicity The lack of an affinity for water.

hygroscopic Ready to take up and retain moisture.


blog comments powered by Disqus

ADVERTISEMENT

ADVERTISEMENT

GPhA Issues Statement on Generic Drug Costs
November 20, 2014
Amgen Opens Single-Use Manufacturing Plant in Singapore
November 20, 2014
Manufacturing Issues Crucial to Combating Ebola
November 20, 2014
FDA Requests Comments on Generic Drug Submission Criteria
November 20, 2014
USP Joins Chinese Pharmacopoeia Commission for Annual Science Meeting
November 20, 2014
Author Guidelines
Source: BioPharm International Supplements,
Click here