Bioterminology - - BioPharm International



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toxicology Study of harmful substances: what they are composed of and which part is harmful, how they exert their effect, whether an antidote exists, and how the antidote works.

trade secret any unpatented and/or unpatentable trade-secret information and proprietary technology of any kind or nature owned by a company, such as a process method, formulation, or other information that adds value to a product or process.

TM trajectory method; The trajectory method treats the ion as a collection of atoms, each one represented by a 12-6-4 potential. The effective potential is obtained by summing over the individual atomic contributions; then trajectories are run in this potential to obtain the scattering angle (the angle between the incoming and departing buffer gas atom trajectory). The orientationally averaged collision integral is determined by averaging over all possible collision geometries.

transcription Synthesis involving RNA polymerase of complementary RNA from a sequence of DNA.

In high-throughput laboratories, batches of samples are processed for screening, confirmation, or profiling purposes.
transdermal delivery Drug delivery across the skin, accomplished without breaking the skin. For large molecules like proteins and peptides, this is possible only through iontophoresis.

transduction The transfer of genetic material from one cell or another by means of virus or phage vector.

transformation A change in the genetic structure of an organism by the incorporation of foreign DNA.

transgenics The alteration of plant or animal DNA so that it contains a gene from another organism. There are two types of cells in animals and plants, germ line cells (the sperm and egg in animals, pollen and ovule in plants) and somatic cells (all of the other cells). Germ-line DNA is altered in transgenic animals and plants so those alterations are passed on to offspring. That is done to produce therapeutics, to study disease, and to improve livestock strains. Transgenic plants have been created for increased resistance to disease and insects as well as to make biopharmaceuticals.

translation The process by which information transferred from DNA by RNA specifies the sequence of amino acids in a polypeptide (protein) chain.

transmucosal delivery Drug delivery across mucosal membranes, such as the nasal lining, the inside of the mouth, or the rectal wall.

treatment IND An IND that makes a promising new drug available to desperately ill patients as early in the drug development process as possible. FDA permits the drug to be used if there is preliminary evidence of efficacy and it treats a serious or life-threatening disease, or if there is no comparable therapy available.

trehalose A sugar (non-reducing disaccharide) found in certain algae and plants, some bacteria, and some insects. It is used as a preservative and stabilizer in some biopharmaceutical formulations.

trend A statistical term referring to the direction or rate of change of a variable(s). [From ICH Q9]

trifluoroacetic acid A nonflammable, hygroscopic (takes up moisture), colorless liquid used as a reagent, solvent, catalyst, and strong nonoxidizing acid.

tRNA TransferRNA; a type of RNA with triplet nucleotide sequences that complement the nucleotide coding sequences of mRNA. In protein synthesis, tRNA bonds with amino acids and transfers them to the ribosomes, where proteins are assembled according to the genetic code carried by mRNA.

Trp Tryptophan; one of more than 20 naturally occurring amino acids.

trypsin An enzyme capable of cleaving peptide bonds. It is used to remove adherent cells from a surface and to break up (digest) purified proteins for analysis.

tryptic fragment analysis Identifying and quantitating the peptides resulting from tryptic digestion.

TSE Transmissible spongiform encephalopathies; neurological disease in mammals of many species, generally believed to be caused by prions.

turbidostat A variation on a chemo-stat. Whereas a chemostat is designed for constant input of medium, a turbidostat is designed to keep the organisms at a constant concentration. A turbidity sensor measures the concentration of organisms in the culture and adds additional medium when a preset value is exceeded.

turbulent flow field The state that results from mixing the contents of a fermentor or bioreactor to provide oxygen to the cells. That must be balanced against the shear that causes cell damage and death.

turnkey system A piece of equipment, process train, or manufacturing plant that is delivered to the customer in a ready-to-run condition, specialized for the customer's application, with no additional equipment or modifications required.

TWIG travelling wave ion guide; the mechanism by which mobility is implemented in an ion mobility capable mass spectrometer, i.e., Waters SYNAPT™ Systems. Ions are moved through a pressurized region by the action of a continuous train of transient voltage pulses, or travelling waves.

Tyr Tyrosine; one of more than 20 naturally occurring amino acids.

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