The Impact of Disposables on Project Economics in a New Antibody Plant: A Case Study - A case study compares capital costs, operating expenses, and net present value for a new MAb plant. - BioPharm

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The Impact of Disposables on Project Economics in a New Antibody Plant: A Case Study
A case study compares capital costs, operating expenses, and net present value for a new MAb plant.


BioPharm International
Volume 22, Issue 12

CONCLUSION

This case study demonstrates that integrating disposable and stainless steel technology in a hybrid model has economic benefits. Using this approach in a 100 kg antibody production plant yielded significant savings in capital expenses, a key factor that may determine the feasibility of an investment project for a small- or medium-sized company. The economic model also showed lower operating costs for the hybrid project, compared to a project based on stainless steel, mainly as a result of lower equipment-related costs and reduced demand for pharmaceutical water. The net present value of the hybrid project, calculated over 10 years, was 68% higher than a similar project based on stainless steel technology.

ACKNOWLEDGEMENTS

We would like to thank Danilo Ponassi of Sartorius Stedim Biotech for his significant contribution to the introduction of disposable technology in CIM processes over more than 10 years.

José M. País Chanfrau is the plant design engineer, Katia Zorrilla is a chemical engineer, and Ernesto Chico is the technical director, all in the Technical Direction department at the Center of Molecular Immunology, Havana, Cuba, +53 7 271 3357,

REFERENCES

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2. Darby N. Trends in biological manufacturing: How will our industry change in the next 10 years? 2nd Annual Bioprocess Technology Seminar & Exhibition, Europe; 2008 June 23–25; Stockholm, Sweden. Available from http://www.asmeconferences.org/BioprocessEurope08/ASMEDarby.pdf

3. Lang HJ. Simplified approach to preliminary cost estimates. Chem Eng. 1948;55:112–113.

4. Petrides D. Bioprocess design and economics. In Harrison RG, Todd PW, Rudge SR, Petrides D, editors. Bioseparations science and engineering. London: Oxford University Press; 2000.

5. Holland FA, Wilkinson JK. Process Economics. In Perry R, Green DW, Maloney JO, editors. Perry´s chemical engineers' handbook. 7th ed. New York: McGraw-Hill Co., Inc.; 1999.

6. Sinclair A, Monge M. How to evaluate the cost impact of using disposables in biomanufacturing. Biopharm Int. 2008; 1(6):26–30.


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