Sterile connectors make operation easier and faster than other methods of connections in an aseptic environment, such as open
manipulations and tube welding, while completing the path of a sterile closed system. Nonetheless, due diligence is required
to ensure that an appropriate connector type is selected and tested to satisfy the user, product requirements, system integrity,
Kirsten A. Strahlendorf is a process development scientist and Kevin Harper is a platform director, both at Sanofi Pasteur, Toronto, Canada, 416.667.2700, firstname.lastname@example.org
1. Steinmetz R, Brown NG, Allen DL, Bigsby RM, Ben-Jonathan N. The environmental estrogen bisphenol A stimulates prolactin
Release in vitro and in vivo. Endocrinol. 1997;138(5)1780–6.
2. Current revision of Code of Federal Regulations, Title 21: Food and Drugs, PART 189—Substances Prohibited from Use in Human
Food, § 189.5 Prohibited cattle materials.
3.Note for guidance on minimizing the risk of transmitting animal spongiform encephalopathy agents via human and veterinary
medicinal products (EMEA 410/01 Rev. 2 – Oct 2003) adopted by the Committee for Proprietary Medicinal Products (CPMP) and
by the Committee for Veterinary Medicinal products (CVMP) Official J EU C 24, 28.1.2004, p. 6.