Tangential Flow Filtration for the Recovery of Acellular Pertussis Vaccine Components - Membrane-based TFF technology can ease scale-up and provide a higher recovery percentage compared to conventio

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Tangential Flow Filtration for the Recovery of Acellular Pertussis Vaccine Components
Membrane-based TFF technology can ease scale-up and provide a higher recovery percentage compared to conventional purification methods.


BioPharm International Supplements


Acknowledgement

The authors are thankful to Lalit Saxena and Gajanan Joshi of Millipore India Pvt. Ltd. for technical assistance during the study.

RAKESH KUMAR, PhD, is a director and S.V. KAPRE, PhD, is an executive director of the Serum Institute of India, Ltd., Pune, India, PRIYABRATA PATTNAIK, PhD, is a technical manager of the biomanufacturing sciences network at Millipore Singapore Pte. Ltd., Singapore, +65.6403.5308,
SUBHASIS BANERJEE, PhD, is a manager of process applications and M.S. MAHADEVAN is a vice president of the bioprocess division at Millipore India Pvt. Ltd., Bangalore, India.

References

1. Cherry JD, Heininger U. Pertussis and other Bordetella infections, In: Feigin RD, Cherry JD, eds. Textbook of Pediatric Infectious Diseases, 4th edn. WB Saunders; Philadelphia, PA. 1998:1423–40.

2. Conly JM, Johnston BL. The role of the acellular pertussis vaccine and the demise of the 'Pertussis Pete'. Can J Infect Dis. 2001:98:15–17.

3. Pertussis Vaccination : Use of Acellular Pertussis vaccines among infants and young children, Recommendations of the advisory committee on immunization practices (ACIP); Morbidity and mortality weekly report, US Department of Health and Human Services. 1997;22: Mar 28.

4. Corbel MJ, Corbel MJ, Toxicity and potency evaluation of pertussis vaccine. Vaccines. 2004:89–100.

5. Sundaran B, Palianiappan C, Rao YUB, Boopathy R, Bhau RLN. Tangential flow filtration technology applicable to large scale recovery of diptheria toxin. J Biosci Bioeng. 2002;94:93–98.

6. Rao YUB, Mahadevan MS, Michaels LS. Evaluation of microporous tangential-flow filtration in the production of diptheria and pertussis vaccines. Pharm Technol. 1992;16:102-110.

7. Stainer DW, Scholte MJ. A simple chemically defined medium for the production of phase I Bordetella pertussis. J Gen Microbiol. 1970;63:211–220.


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