Opalescence of an IgG1 Monoclonal Antibody Formulation is Mediated by Ionic Strength and Excipients - Can increase in ionic strength result in higher viscosity? - BioPharm International

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Opalescence of an IgG1 Monoclonal Antibody Formulation is Mediated by Ionic Strength and Excipients
Can increase in ionic strength result in higher viscosity?


BioPharm International
Volume 22, Issue 4

17. Winzor DJ, Deszczynski M, Harding SE, Wills PR. Nonequivalence of second virial coefficients from sedimentation equilibrium and static light scattering studies of protein solutions. Biophys Chem. 2007;128:46–55.

18. Bajaj H, Sharma VK, Badkar A, Zeng D, Nema S, Kalonia DS. Protein structural conformation and not second virial coefficient relates to long-term irreversible aggregation of a monoclonal antibody and ovalbumin in solution. Pharm Res. 2006;23:1382–94.

19. George A, Wilson WW. Predicting protein crystallization from a dilute solution property. Acta Crystallogr D Biol Crystallogr. 1994;50:3–5.

20. Valente JJ, Verma KS, Manning MC, Wilson WW, Henry CS. Second virial coefficient studies of cosolvent-induced protein self-interaction. Biophys J. 2005;89:4211–8.

21. Shi L, Sanyal G, Ni A et al. Stabilization of human papillomavirus virus-like particles by non-ionic surfactants. J Pharm Sci. 2005;94:1538–51.

22. Liu J, Nguyen MD, Andya JD, Shire SJ. Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution. J Pharm Sci. 2005;94:1928–40.

23. Baldwin RL. How Hofmeister ion interactions affect protein stability. Biophys J. 1996;71:2056–63.

24. Ionescu RM, Shi L. Thermal unfolding of proteins. The encylopedia of industrial biotechnology: bioprocess, bioseparation, and cell technology. 2008. John Wiley & Sons, Inc. In Press.

25. Ionescu RM, Vlasak J, Price C, Kirchmeier M. Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies. J Pharm Sci. 2008;97:1414–26.

26. Payne RW, Nayar R, Tarantino R et al. Second virial coefficient determination of a therapeutic peptide by self-interaction chromatography. Biopolymers. 2006;84:527–33.

27. Rosenbaum DF, Zukoski CF. Protein interactions and crystallization. J Crystal Growth. 1996;169:752–8.

28. Moore JM, Patapoff TW, Cromwell ME. Kinetics and thermodynamics of dimer formation and dissociation for a recombinant humanized monoclonal antibody to vascular endothelial growth factor. Biochem. 1999;38:13960–7.

29. Kameoka D, Masuzaki E, Ueda T, Imoto T. Effect of buffer species on the unfolding and the aggregation of humanized IgG. J Biochem. 2007;142:383–91.


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