Antibody Purification Using Membrane Adsorbers - Results from a process developed for a commercial antibody. - BioPharm International

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Antibody Purification Using Membrane Adsorbers
Results from a process developed for a commercial antibody.


BioPharm International
Volume 21, Issue 12

REFERENCES

1. Daemmrich A, Browden ME. A rising drug industry. Chem Eng News. 2005;Jun:28–42.

2. Gottschalk U. New and unknown challenges facing biomanufacturing. BioPharm Int. 2005; 18(3):24–28.

3. Thoemmes J, Kula MR. Membrane chromatography. An integrative concept in the downstream processing of proteins. Biotechnol Prog. 1995;11:357–367.

4. Zhou J, Tressel T. Basic concepts in Q membrane chromatography for large-scale antibody production. Biotechnol Prog. 2006;22:341–349.

5. Etzel M, Riordan W. Membrane chromatography: Analysis of breakthrough curves and viral clearance. In: Shukla A, Etzel M, Gadam S, editors. Process Scale Bioseparations for the Biopharmaceutical Industry. Boca Raton, FL:Taylor & Francis;2006.

6. Walter JK. Strategies and considerations for advanced economy in downstream processing of biopharmaceutical proteins. In: Subramanian G, editor. Bioseparation and bioprocessing. processing, quality and characterization, economics, safety and hygiene. New York: Wiley VCH; 1998. p. 447–460.

7. Gebauer KH, Thömmes J. Kula MR. Breakthrough performance of high-capacity membrane adsorbers in protein chromatography. Chem. Eng Sci. 1997;52:405–419.

8. Gottschalk U. Bioseparation in antibody manufacturing: The good, the bad and the ugly. Biotechnol Prog. 2008 (in press).

9. Norling L, et al. Impact of multiple reuse of anion exchange chromatography media on virus removal. J Chromatogr. 2005;1069:79–89.

10. Zhou JX, et al. New Q membrane scale-down model for process-scale antibody purification. J Chromatogr A. 2006;1134,66–73.

11. Marlind J, et al. Clin Cancer Res. 2008 Oct 15;14(20):6515-24.

12. Zhou J, Tressel T. Q membrane chromatography as a robust purification unit for large-scale antibody production. BioProcess Intl. 2005;3(suppl):32–37.

13. Kelley B. Very large scale monoclonal antibody purification: the case for conventional unit operations. Biotechnol Prog. 2007;23:995–1008.

14. Curling J, Gottschalk U. Process chromatography: Five decades of innovation. BioPharm Int. 2007;20:10–19.


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