Antibody Purification Using Membrane Adsorbers - Results from a process developed for a commercial antibody. - BioPharm International

ADVERTISEMENT

Antibody Purification Using Membrane Adsorbers
Results from a process developed for a commercial antibody.


BioPharm International
Volume 21, Issue 12

REFERENCES

1. Daemmrich A, Browden ME. A rising drug industry. Chem Eng News. 2005;Jun:28–42.

2. Gottschalk U. New and unknown challenges facing biomanufacturing. BioPharm Int. 2005; 18(3):24–28.

3. Thoemmes J, Kula MR. Membrane chromatography. An integrative concept in the downstream processing of proteins. Biotechnol Prog. 1995;11:357–367.

4. Zhou J, Tressel T. Basic concepts in Q membrane chromatography for large-scale antibody production. Biotechnol Prog. 2006;22:341–349.

5. Etzel M, Riordan W. Membrane chromatography: Analysis of breakthrough curves and viral clearance. In: Shukla A, Etzel M, Gadam S, editors. Process Scale Bioseparations for the Biopharmaceutical Industry. Boca Raton, FL:Taylor & Francis;2006.

6. Walter JK. Strategies and considerations for advanced economy in downstream processing of biopharmaceutical proteins. In: Subramanian G, editor. Bioseparation and bioprocessing. processing, quality and characterization, economics, safety and hygiene. New York: Wiley VCH; 1998. p. 447–460.

7. Gebauer KH, Thömmes J. Kula MR. Breakthrough performance of high-capacity membrane adsorbers in protein chromatography. Chem. Eng Sci. 1997;52:405–419.

8. Gottschalk U. Bioseparation in antibody manufacturing: The good, the bad and the ugly. Biotechnol Prog. 2008 (in press).

9. Norling L, et al. Impact of multiple reuse of anion exchange chromatography media on virus removal. J Chromatogr. 2005;1069:79–89.

10. Zhou JX, et al. New Q membrane scale-down model for process-scale antibody purification. J Chromatogr A. 2006;1134,66–73.

11. Marlind J, et al. Clin Cancer Res. 2008 Oct 15;14(20):6515-24.

12. Zhou J, Tressel T. Q membrane chromatography as a robust purification unit for large-scale antibody production. BioProcess Intl. 2005;3(suppl):32–37.

13. Kelley B. Very large scale monoclonal antibody purification: the case for conventional unit operations. Biotechnol Prog. 2007;23:995–1008.

14. Curling J, Gottschalk U. Process chromatography: Five decades of innovation. BioPharm Int. 2007;20:10–19.


blog comments powered by Disqus

ADVERTISEMENT

ADVERTISEMENT

NIH Launches Human Safety Study of Ebola Vaccine Candidate
August 29, 2014
Suppliers Seek to Boost Single-Use Technology
August 21, 2014
Bristol-Myers Squibb and Celgene Collaborate on Immunotherapy and Chemotherapy Combination Regimen
August 20, 2014
FDA Warns about Fraudulent Ebola Treatments
August 15, 2014
USP Awards Analytical Research
August 15, 2014
Author Guidelines
Source: BioPharm International,
Click here