How to Evaluate the Cost Impact of Using Disposables in Biomanufacturing - To understand the overall cost impact of disposable technologies, it is necessary to build a robust model that covers the ent

ADVERTISEMENT

How to Evaluate the Cost Impact of Using Disposables in Biomanufacturing
To understand the overall cost impact of disposable technologies, it is necessary to build a robust model that covers the entire process.


BioPharm International
Volume 21, Issue 6

SUMMARY

I hope I have given some insight into how cost models are being used to evaluate the use of disposables technologies in biopharmaceutical manufacturing. I believe that the current focus on COGS models is underplaying the benefits of disposables technology. Typically, disposable technologies result in quicker builds of new facilities or manufacturing suites and reduced capital expenditures. The financial analysis should capture these benefits by accounting for this delay in spending (thereby reducing the project risk). The best method for accounting for these benefits is through the use of NPV analysis.

Andrew Sinclair is the managing director of Biopharm Services, Chesham, Bucks, UK, +44 1494 793 243,

REFERENCES

1. Sinclair A, Monge M. Biomanufacturing for the 21st century: Designing a concept facility based on single-use systems. Bioprocess Int. 2004 Oct supp;26–31.

2. Lim J, Sinclair A, Kim D, Gottschalk U. Economic benefits of single-use membrane chromatography in polishing: a cost of goods model. Bioprocess Int. 2007 Feb; 5(2):48–56.

3. Van Reiss R. Genentech. IBC IBC Bioeconomics Conference; 1999; Washington, DC.

4. Lim J, Sinclair A. Process economy of disposable manufacturing. Process models to minimize upfront investment. Amer Pharm Rev. 2007 Sept/Oct;10(6):114–21.

5. Sinclair A, Monge M. Concept facility based on single-use systems, part 2. Leading the way for biomanufacturing in the 21st century. BioProcess Int. 2005 Oct supp;51–55.


blog comments powered by Disqus

ADVERTISEMENT

ADVERTISEMENT

FDA Approves Pfizer's Trumenba for the Prevention of Meningitis B
October 30, 2014
EMA: Extrapolation Across Indications for Biosimilars a Possibility
October 30, 2014
Bristol-Myers Squibb Announces Agreement to Acquire HER2-Targeted Cancer Treatment
October 29, 2014
Contract Research and Manufacturing Organization Paragon Bioservices Raises $13 Million
October 28, 2014
Yale and Gilead Extend Sequencing Initiative
October 28, 2014
Author Guidelines
Source: BioPharm International,
Click here