Filter Clogging Issues in Sterile Filtration - - BioPharm International

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Filter Clogging Issues in Sterile Filtration


BioPharm International
Volume 21, Issue 4

Ashutosh Sharma is senior engineer and Anurag S. Rathore, PhD, is a director of process development at Amgen,Inc.,Thousand Oaks,CA, 805.447.4491,
Anurag Rathore is also a member of BioPharm International's editorial advisory board. Sean Anderson is a graduate student at the chemical and biomolecular engineering department,University of California at Los Angeles, Los Angeles,CA.

REFERENCES

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2. Syedain ZH, Bohonak DM, Zydney AL. Protein fouling of virus filtration membranes: effects of membrane orientation and operating conditions. Biotechnol Prog. 2006;22:1163–169.

3. Kelly ST, Zydney AL. Effects of intermolecular thiol-disulfide interchange reactions on BSA fouling during microfiltration. Biotech Bioeng. 1994;44:972–982.

4. Higuchi A, Kyokon M, Murayama S, Yokogi M., Hirasaki T, Manabe S. Effect of aggregated protein sizes on the flux of protein solution through microporous membranes. J Mem Sci. 2004;236:137–144.

5. Ho CC, Zydney AL. A combined pore blockage and cake filtration model for protein fouling during microfiltration. J Colloid Inter Sci. 2000;232:389–399.

6. Bowen WR, Gan Q. Properties of microfiltration membranes: flux loss during constant pressure permeation of bovine serum albumin. Biotech Bioeng. 1991;38:688–696.

7. Andya JD, Hsu CC, Shire SJ. Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations. AAPS PharmSci 5. 2003;(2) Article 10. Available from http://www.pharmsci.org/.

8. Marshall AD, Munro PA, Tragardh G. The effect of protein fouling in microfiltration and ultrafiltration on permeate flux, protein retention and selectivity: A literature review. Desalination. 1993;91:65–108.

9. Saksena S, Zydney AL. Effect of solution pH and ionic strength on the separation of albumin from immunoglobulins (IgG) by selective filtration. Biotech Bioeng. 1994;43:960–968.

10. Maa YF, Hsu CC. Membrane fouling in sterile filtration of recombinant human growth hormone. Biotech Bioeng. 1996;50:319–328.

11. Maa YF, Hsu CC. Investigation on fouling mechanisms for recombinant human growth hormone sterile filtration. J Pharm Anal. 1998;87:808–812.

12. Hlavacek M, Bouchet F. Constant flowrate blocking laws and an example of their application to dead-end microfiltration of protein solutions. J Mem Sci. 1993;82:285–295.

13. Hermia J. constant pressure blocking filtration laws—application to power-law non-newtonian fluids. Trans IChemE. 1982;60:183–87.


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