Filter Clogging Issues in Sterile Filtration - - BioPharm International

ADVERTISEMENT

Filter Clogging Issues in Sterile Filtration


BioPharm International
Volume 21, Issue 4

Ashutosh Sharma is senior engineer and Anurag S. Rathore, PhD, is a director of process development at Amgen,Inc.,Thousand Oaks,CA, 805.447.4491,
Anurag Rathore is also a member of BioPharm International's editorial advisory board. Sean Anderson is a graduate student at the chemical and biomolecular engineering department,University of California at Los Angeles, Los Angeles,CA.

REFERENCES

1. Kelly ST, Zydney AL. Mechanisms for BSA fouling during microfiltration. J Mem Sci. 1995;107:115–127.

2. Syedain ZH, Bohonak DM, Zydney AL. Protein fouling of virus filtration membranes: effects of membrane orientation and operating conditions. Biotechnol Prog. 2006;22:1163–169.

3. Kelly ST, Zydney AL. Effects of intermolecular thiol-disulfide interchange reactions on BSA fouling during microfiltration. Biotech Bioeng. 1994;44:972–982.

4. Higuchi A, Kyokon M, Murayama S, Yokogi M., Hirasaki T, Manabe S. Effect of aggregated protein sizes on the flux of protein solution through microporous membranes. J Mem Sci. 2004;236:137–144.

5. Ho CC, Zydney AL. A combined pore blockage and cake filtration model for protein fouling during microfiltration. J Colloid Inter Sci. 2000;232:389–399.

6. Bowen WR, Gan Q. Properties of microfiltration membranes: flux loss during constant pressure permeation of bovine serum albumin. Biotech Bioeng. 1991;38:688–696.

7. Andya JD, Hsu CC, Shire SJ. Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations. AAPS PharmSci 5. 2003;(2) Article 10. Available from http://www.pharmsci.org/.

8. Marshall AD, Munro PA, Tragardh G. The effect of protein fouling in microfiltration and ultrafiltration on permeate flux, protein retention and selectivity: A literature review. Desalination. 1993;91:65–108.

9. Saksena S, Zydney AL. Effect of solution pH and ionic strength on the separation of albumin from immunoglobulins (IgG) by selective filtration. Biotech Bioeng. 1994;43:960–968.

10. Maa YF, Hsu CC. Membrane fouling in sterile filtration of recombinant human growth hormone. Biotech Bioeng. 1996;50:319–328.

11. Maa YF, Hsu CC. Investigation on fouling mechanisms for recombinant human growth hormone sterile filtration. J Pharm Anal. 1998;87:808–812.

12. Hlavacek M, Bouchet F. Constant flowrate blocking laws and an example of their application to dead-end microfiltration of protein solutions. J Mem Sci. 1993;82:285–295.

13. Hermia J. constant pressure blocking filtration laws—application to power-law non-newtonian fluids. Trans IChemE. 1982;60:183–87.


blog comments powered by Disqus

ADVERTISEMENT

ADVERTISEMENT

PDA Announces Technical Report on Drug Shortages
September 9, 2014
European Commission Approves RoACTEMRA for Treatment of RA
September 9, 2014
DPT Laboratories Acquires Media Pharmaceuticals' Lakewood Facilities
September 5, 2014
Merck KGaA Breaks Ground on Facility in China
September 5, 2014
FDA Releases Guidance Electronic Submission of Lot Distribution Reports
September 5, 2014
Author Guidelines
Source: BioPharm International,
Click here