An Improved Manufacturing Process for a Recombinant Polyprotein Vaccine - Combating the devastating global disease of leishmaniasis with a new therapeutic and prophylactic vaccine - BioPharm

ADVERTISEMENT

An Improved Manufacturing Process for a Recombinant Polyprotein Vaccine
Combating the devastating global disease of leishmaniasis with a new therapeutic and prophylactic vaccine


BioPharm International


12. Badaro R, Lobo I, Nakatani M, Muinos A, Netto EM, Coler RN, Reed SG. Successful use of a defined antigen/GM-CSF adjuvant vaccine to treat mucosal leishmaniasis refractory to antimony: A case report. Braz J Infect Dis. 2001;5:223–32.

13. Campos-Neto A, et al. Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primate models of the human disease. Infect and Immun. 2001;69:4103–8.

14. Campos-Neto A, Webb JR, Greeson K, Coler RN, Skeiky YA, Reed SG. Vaccination with plasmid DNA encoding TSA/LmSTI1 leishmanial fusion proteins confers protection against Leishmania major infection in susceptible BALB/c mice. Infect and Immun. 2002;70:2828–36.

15.Webb JR, Kaufmann D, Campos-Neto A, Reed SG. Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine leishmaniasis. J Immunol. 1996;157:5034–41.

16. Webb JR, et al. Human and murine immune responses to a novel Leishmania major recombinant protein encoded by members of a multicopy gene family. Infection and Immunity. 1998;66:3279–89.

17. Skeiky YA, et al. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. J Exp Med. 1995;181:1527–37.

18. Titus RG, Gueiros-Filho FJ, De Freitas LA, Beverley SM. Development of a safe live Leishmania vaccine line by gene replacement. Proc Natl Acad Sci USA. 1995;92:10267–71.

19. Knorst MT, Neubert R, Wohlrab W. Analytical methods for measuring urea in pharmaceutical formulations. J Pharm Biomed Analysis. 1997;15:1627–32.

20. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680–5.


blog comments powered by Disqus

ADVERTISEMENT

ADVERTISEMENT

GSK Submits EU Regulatory Filing for Malaria Vaccine Candidate
July 29, 2014
Bristol-Myers Squibb and Ono Pharmaceutical Collaborate on Immunotherapies
July 28, 2014
FDA Accepts First Biosimilar Filing
July 24, 2014
Compounding Pharmacy Issues Recall, But Challenges FDA Decision
July 22, 2014
AbbVie's Acquisition of Shire Could Save $8 Billion in Taxes
July 21, 2014
Author Guidelines
Source: BioPharm International,
Click here