The Evolution of Protein Expression and Cell Culture - - BioPharm International


The Evolution of Protein Expression and Cell Culture

BioPharm International
Volume 20, Issue 10


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2. Gasser B, Mattanovich D. Antibody production with yeasts and filamentous fungi: on the road to large scale? Biotechnol Lett. 2007;29(2):201–212.

3. Safdar A, Cox MM. Baculovirus-expressed influenza vaccine. A novel technology for safe and expeditious vaccine production for human use. Expert Opin Investig Drugs. 2007;16(7):927–934.

4. Boehm R. Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms. Ann N Y Acad Sci. 2007;1102:121–134.

5. Bout A, Hateboer G, Verhulst KC, Uytdehaag AG, Schouten GJ, inventors; Holland C, assignee. Recombinant protein production in a human cell. US patent 10,234,007. 2006 Nov.

6. Salamone D, Baranao L, Santos C, Bussmann L, Artuso J, Werning C, et al. High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow. J Biotechnol. 2006;124(2):469–472.

7. Hamilton SR, Davidson RC, Sethuraman N, Nett JH, Jiang Y, Rios S, et al. Humanization of yeast to produce complex terminally sialylated glycoproteins. Science. 2006;313(5792):1441–1443.

8. Stomp AM. The duckweeds: a valuable plant for biomanufacturing. Biotechnol Ann Rev. 2005;11:69–99.

9. Calhoun KA, Swartz JR. Energizing cell-free protein synthesis with glucose metabolism. Biotechnol Bioeng. 2005;90(5):606–613.

10. Le Hir H, Nott A, Moore MJ. How introns influence and enhance eukaryotic gene expression. Trends Biochem Sci. 2003;28(4):215–220.

11. Barrett JW, Sun Y, Nazarian SH, Belsito TA, Brunetti CR, McFadden G. Optimization of codon usage of poxvirus genes allows for improved transient expression in mammalian cells. Virus Genes. 2006 Aug;33(1):15–26.

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15. Benton T, Chen T, McEntee M, Fox B, King D, Crombie R, et al. The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein. Cytotechnol. 2002 Jan;38(1–3):43–46.

16. Kwaks THJ, Barnett P, Hemrika W, Siersma T, Sewalt RGAB, Satijn DPE, et al., Identification of anti-repressor elements that confer high and stable protein production in mammalian cells. Nat Biotechnol. 2003;21(7):553–558.

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19. Davies A, Greene A, Lullau E, Abbott WM. Optimisation and evaluation of a high-throughput mammalian protein expression system. Protein Expr Purif. 2005 Jul;42(1):111–21.

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