Filtration Designs Remove Processing Bottlenecks for High-Yield Biotech Drugs - Deep pleats and asymmetric pores increase the capacity and lifetime of a cartridge - BioPharm International

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Filtration Designs Remove Processing Bottlenecks for High-Yield Biotech Drugs
Deep pleats and asymmetric pores increase the capacity and lifetime of a cartridge


BioPharm International


Vaccines


Figure 6. Water flowrates per 10-inch cartridge
To filter a batch of 100 L of vaccine product a total of six traditional nylon filters would be used. The same batch can be filtered with one deep pleated PES filter (Table 5). The deep pleat design and asymmetric pore structure allows end users to reduce the number and size of filter assemblies. Smaller filter assemblies mean fewer components to sterilize, test, clean, and validate.

Monoclonal Antibodies

To process a 550 L batch of monoclonal product, two high-flow PES filters are required. The same batch can be filtered with one high-capacity hybrid filter (Table 6).


Quick Recap
As these examples have shown, however a manufacturer chooses to realize the benefits of innovative filter technology, the end result is more efficient and faster processing of lifesaving drugs.


MONICA CARDONA is a marketing manager with Western Hemisphere responsibility for direct flow filtration with Pall Corporation, 516.801.9526, fax 516.801.9548,

OLIVER G. INSEAL is an R&D mechanical engineer at Pall Corporation Life Sciences Department, +44.23.9230.3300, Oliver G.


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