To filter a batch of 100 L of vaccine product a total of six traditional nylon filters would be used. The same batch can be
filtered with one deep pleated PES filter (Table 5). The deep pleat design and asymmetric pore structure allows end users
to reduce the number and size of filter assemblies. Smaller filter assemblies mean fewer components to sterilize, test, clean,
Figure 6. Water flowrates per 10-inch cartridge
To process a 550 L batch of monoclonal product, two high-flow PES filters are required. The same batch can be filtered with
one high-capacity hybrid filter (Table 6).
As these examples have shown, however a manufacturer chooses to realize the benefits of innovative filter technology, the
end result is more efficient and faster processing of lifesaving drugs.
MONICA CARDONA is a marketing manager with Western Hemisphere responsibility for direct flow filtration with Pall Corporation, 516.801.9526,
fax 516.801.9548, firstname.lastname@example.org
OLIVER G. INSEAL is an R&D mechanical engineer at Pall Corporation Life Sciences Department, +44.23.9230.3300, Oliver G. Inseal@pall.com