Chromatography Process Development Using 96-Well Microplate Formats - One plate can test one adsorbent in two days for its optimum condition. Results are confirmed in a laboratory column.

Chromatography Process Development Using 96-Well Microplate Formats - One plate can test one adsorbent in two days for its optimum condition. Results are confirmed in a laboratory column. - BioPharm

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Chromatography Process Development Using 96-Well Microplate Formats

One plate can test one adsorbent in two days for its optimum condition. Results are confirmed in a laboratory column.

Jun 2, 2006
By: Henry Charlton, Ben Galarza, Kelly Leriche, Rob Jones
BioPharm International

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Summary

Quick Recap

Using 96-well microplates for chromatography adsorbent selection and process development may expedite typical activities undertaken by process development groups.

Using such a format requires smaller sample volumes and can rapidly generate data from a number of points than might otherwise be possible in the same time frame. As a result, this method is likely to be of benefit in this important area of biopharmaceutical process development. Furthermore, using these high throughput experimental techniques increases the number of adsorbents or process conditions that can be evaluated, potentially resulting in substantial time and cost savings in process development activities.

HENRY CHARLTON, PH.D. is team leader at Prometic BioSciences Ltd., 211 Cambridge Science Park, Cambridge, CB4 0ZA, UK, +44.1223.420300, fax +44.1223.433270, henry.charlton@prometic.co.uk

BEN GALARZA ben.galarza@prometic.com

BEN BEACON ben.beacon@prometic.com

and KELLY LERICHE Kelly.leriche@prometic.com
are all research scientists,

and ROB JONES rob.jones@prometic.com
is shipping and transport manager.

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