Maximizing Protein Expression in Filamentous Fungi - Filamentous fungi are efficient protein producers that hold great promise for shortening product development cycles. - BioPharm International

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Maximizing Protein Expression in Filamentous Fungi
Filamentous fungi are efficient protein producers that hold great promise for shortening product development cycles.


BioPharm International
Volume 19, Issue 5

REFERENCES

1. Punt PJ, van Biezen N, Conesa A, Albers A, Mangnus J, van den Hondel C. Filamentous fungi as cell factories for heterologous protein production. Trends Biotechnol. 2002; 20:200-6.

2. Nevalainen HKM, Valentino TSJ, Bergquist PL. Heterologous protein expression in filamentous fungi. Trends Biotechnol. 2005; 23:468-74.

3. Maras M, van Die I, Contreras R, van den Hondel. CAMJJ. Filamentous fungi as production organisms for glycoproteins of biomedical interest. Glycoconjugate J. 1999; 16, 99-107.

4. Van den Hombergh JPTW, van der Vondervoort PJI, Fraissinet-Tachet L, and Visser J. Aspergillus as a host for heterologous protein production: the problem of proteases. 1997;TIBTECH 15: 256-63.

5. Ward M, Wilson LJ, and Kodama KH. Use of Aspergillus overproducing mutants, cured of integrated plas-mid, to overproduce heterologous proteins. Appl. Microbiol. Biotechnol. 1993; 39:738-43.

6. Hamilton SR, Bobrowicz P, Bobrowicz B, Davidson RC, Li H, Mitchell T, et al. Production of complex glycoproteins in yeast. Science.2003; 301:1244-46.

7. Neose Technologies, nc., Horsham Pa.. Available at: http://www.neose.com/.

8. Dai Z, Mao X, Magnuson JK, Lasure LL. Identification of genes associated with morphology in Aspergillus niger by using suppressive subtractive hybridization. Appl. Environ. Microbiol. 2004; 70:2474-85.

9. Bhargava S, Wenger KS, Marten MR. Pulsed addition of limiting-carbon during Aspergillus oryzae fermentation leads to improved productivity of a recombinant enzyme. Biotechnol. Bioengineering. 2003;82:111-17.

10. National Center for biotechnology Information. Bethesda Md. Available at: http://www.ncbi.nlm.nih.gov/genomes/leuks.cgi?p3=11:Fungi&taxgroup=11:Fungi|12.

11. Burlingame RP, Chandra R. Gene discovery and protein production technology. An integrated system to discover, develop, and manufacture enzymes and other proteins. Industrial Biotechnol. 2005;1:35-7.

12. Punt PJ, van Zeijl C, van den Hondel C. High-throughput screening of expressed DNA libraries in filamentous fungi. World Patent WO 01/79958. 2001 Oct 25.


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