Cleaning Polyethersulfone Membranes After Ultrafiltration-Diafiltration in Monoclonal Antibody Production - Polyethersulfone membranes can be cleaned safely, effectively, and economically. - BioPharm

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Cleaning Polyethersulfone Membranes After Ultrafiltration-Diafiltration in Monoclonal Antibody Production
Polyethersulfone membranes can be cleaned safely, effectively, and economically.


BioPharm International
Volume 19, Issue 4

ACKNOWLEDGEMENTS

The authors would like to acknowledge Sylvia Isaacson and Mani Krishnan from Millipore Corporation for their valuable technical discussions, and the QA/QC group at Human Genome Sciences, Inc., for their assistance with the TOC analysis.

Yaling Wu is senior scientist I in purification sciences department at Human Genome Sciences,Inc., 14200 Shady Grove Road, Rockville, MD 20850; 301.610.5790;
Amal Ahmed is bioprocess associate III at HGSI purification sciences department. David Kahn is director of purification sciences department of HGSI. Ruta Waghmare is group leader, process development sciences at Millipore Corporation, Billerica MA 01821.

REFERENCES

1. Krack R. Chemical agents and costs in cleaning and disinfection of membranes, equipment. In: Fouling and Cleaning in Pressure Driven Membrane Processes. Brussels: FIL-IDF (IDF special issue 9504); 1995;151-74.

2. Bird MR, Barlett M. CIP optimization for the food industry: relationships between detergent concentration, temperature, and cleaning time. Trans Inst Chem Eng J. 1995; 73:63-70.

3. Crawford JG, Stober SR. Preparation of soluble chymosin or prochymosin from recombinant E. coli - by solubilizing with urea and renaturing, with removal of urea by UF for recycle and specific membrane cleaning procedure Patent EP0657466. 1995.

4. Sayed RSK, Harris JL, Sherkat F. Fouling and cleaning of membranes in the ultrafiltration of the aqueous extract of soy flour. J Membr Sci. 1996; 114:93-04.

5. Zhao Y-J, Wu K-F, Wang Z.-J, Zhao L, Li S-S. Fouling and cleaning of membrane — a literature review. J. of Environmental Sciences 2000; 12(2):240-51.

6. D'Souza NM, Mawson AJ. Membrane cleaning in the dairy industry: A review. Critical Review in Food Science and Nutrition 2005; 45:25-34.

7. Davis M, Abraham S-J. Qualification of a sodium hydroxide/sodium hypochlorite cleaning regimen for ultrafiltration membranes. Abstracts of Papers American Chemical Society 2002; 224(1-2):BIOT 264.


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