Alexander Fleming's original process for making penicillin was a low-volume, and presumably, labor-intensive affair. Today,
it is a highly optimized, low-budget operation that is carried out only overseas. In other words, says Wei-Shou Hu, PhD, of
the University of Minnesota, we engineered ourselves out of a job. Could we do the same with mammalian cell culture? Hu posed
this question during a presentation at the BIO conference in April.
Hu's suggestion is challenging, not only from a technical and scientific standpoint, but from an emotional and economic one.
The idea of seeing one's job disappear as a result of engineering advances is frightening. In the 1951 film, "The Man in the
White Suit," Alec Guinness's character invents a fabric that never stains or wears out. He is thrilled with his invention,
but the workers at the suit plant—and the company's management—are not.
The movie's story uses a somewhat fanciful example, but throughout history, many jobs, and even industries, have become obsolete,
and both workers and management have resisted all along the way. The Luddites were not unique to early nineteenth century
England; they are all of us, a motif that is repeated century after century. Does the oil industry really want us to drive
alternative-fuel cars—or even fuel-efficient ones? Does the egg-based vaccine industry really want to convert to cell-culture
Hu's question poses a somewhat different scenario, however, one that is not simply about powerlessly finding oneself in a
function that is no longer needed. It's about actively pursuing such change as a goal, and changing one's identity and role
in the process.
The Juvenile Diabetes Research Foundation embraces that approach. Their mission is to cure the disease, and thus eliminate
the need for their organization.
I believe it was the French poet Paul Valery who predicted that the poets of the twenty-first century would not be writing
poetry. To a poet, such a thought could be considered blasphemous. Yet the idea presents an open-ended list of opportunities.
What mission would you embark on if your current role were no longer needed?