Cytovance Biologics helps companies developing biopharmaceutical products derived from mammalian cell culture to move their
products rapidly and cost-effectively into and through clinical development. We offer a comprehensive portfolio of process
development, cGMP cell banking and cGMP manufacturing services under reasonable business terms that have been developed based
on our strong client-side experience and intimate knowledge of the technical and business challenges facing companies developing
antibody and recombinant glycoprotein products. Cytovance's team has been involved in the development and production of numerous
products that are now marketed throughout the world. We bridge the "value gap" for those seeking world class expertise and
facilities from a flexible, cost-effective and service oriented CMO.
Cytovance Biologics' customers range from virtual biotechnology companies to major corporations. We focus on process development
and early phase clinical projects where we are able to add value by accelerating projects and providing a high degree of flexibility.
In addition to undertaking complete development projects we are happy to take-on smaller "standalone" projects and process
troubleshooting or technology evaluation work. Our operations are supported by carefully designed quality laboratories, systems
and procedures and highly experienced quality assurance and quality control staff.
Our comprehensive offering of process development services covers cell line development and selection through the design and
development of cell culture and purification processes that are compliant, robust, scaleable, and economically viable. We
also offer a comprehensive analytical development and validation capability. Cytovance offers a full cGMP cell banking and
storage capability and the production of both preclinical and cGMP clinical material is provided at scales up to 500-L (w/v)
bioreactors. Both fed-batch and perfusion capabilities are available.
We are happy to assist with the development of appropriate regulatory submissions and to attend meetings with international
regulatory authorities. We offer considerable experience in technology transfer and fully assist in transferring processes
out of, as well as in to, Cytovance Biologics. We have a successful track record of transferring processes for large-scale
production at international third-party facilities.
Cytovance Biologics operates from three state-of-the-art facilities located on the Presbyterian Health Foundation Research
Park in Oklahoma City, OK. The combination of these world class facilities, which meet international regulatory standards,
and Cytovance's highly experienced management and technical staff allow us to offer service more usually anticipated from
major multinational providers while maintaining the advantage of an attractive cost-basis that we share with our customers.
Our custom-designed 44,000-sq. ft. multi-product cGMP primary production facility features multiple cell culture suites with
bioreactor working volumes up to 500 L. Both fed-batch and perfusion culture are available and are supported by appropriately
scaled purification suites. This facility features expansion space that will allow delivery of larger scale production on
either a multi-product or client-specific basis.
Cytovance's cGMP cell banking and storage practice is located in 6,000 sq. ft. of adjacent cleanroom space that also features
three large cGMP processing suites for client-dedicated or custom processes. Extremely well equipped process development and
quality laboratories are located in a third building adjacent to the manufacturing facilities.
CYTOVANCE BIOLOGICS LLC
840 Research Parkway,
Oklahoma City, OK 73104