Sponsored Whitepapers

Feb 02, 2017
Sponsored Content
Detection and quantification of peptides from transmembrane proteins is important for detection of biomarkers and new protein based drugs. This paper presents a fully automated online digestion and LCMS MRM analysis of two model transmembrane proteins, a method that improves reproducibility and decreases chances of contamination.
Dec 14, 2016
Sponsored Content
A recent report published by the Economist Intelligence Unit, The Changing Biopharma Risk Equation, revealed that biopharma executives were eager to explore new possibilities – from developing novel therapies to expanding in emerging markets. However, they were also concerned about risks, especially regulatory uncertainty. In this Q&A, Heike Michaelis shares her thoughts on the evolving regulatory landscape and what this means for the future of biopharma.
Dec 07, 2016
Sponsored Content
This work demonstrates the use of an ACQUITY UPLC Glycoprotein BEH Amide, 300Å, 1.7 µm Column to obtain HILIC separations of glycopeptides that complement the chromatographic information afforded by a reversed-phase separation.
Nov 30, 2016
Sponsored Content
Learn why the Thermo Scientific™ Vanquish™ Flex UHPLC system is used for efficient and reliable peptide mapping experiments.
Nov 30, 2016
Sponsored Content
Learn how the benefits of a fast analytical platform employing highly efficient chromatography in combination with fast and high-resolution quadrupole Thermo Scientific™ Orbitrap™ mass spectrometry technology as a tool for fast identification and quantification of sequence truncations, glycosylation and post-translational or artificial modification of recombinant monoclonal antibodies.
Nov 30, 2016
Sponsored Content
Learn how to construct a simple time course experiment to identify the digestion endpoint for a given protein by monitoring degradation of the intact protein. The method is simple and uses LC-UV detection. Ribonuclease A, a small, heat stable protein, and mouse IgG, a large immunoglobulin, are used as test probes.
Nov 23, 2016
Sponsored Content
There have been several high profile reports related to the appearance of glass lamellae in parenteral pharmaceutical solutions. We discuss the best approach to identifying the problems through multiple analytical approaches.
Nov 19, 2016
Sponsored Content
Biotherapeutic proteins show promise for improving human health. Drug safety and efficacy are concerns for the manufacturer and regulatory agencies. Consequently, evaluation of anti-drug antibody (ADA) responses is important.
Nov 18, 2016
Sponsored Content
Designing an extractables and leachables project requires understanding the current trends in industry. There are various guidance documents including those listed in the USP as well as those from industry work groups. While all of the guidances provide information on performing studies none of these guidances are prescriptive. This whitepaper provides a brief assessment of these guidances and typical approaches utilized.
Nov 16, 2016
Sponsored Content
A recent report published by the Economist Intelligence Unit, The Changing Biopharma Risk Equation, revealed that biopharma executives were eager to explore new possibilities – from developing novel therapies to expanding in emerging markets. However, they were also concerned about risks, especially regulatory uncertainty. In this Q&A, Heike Michaelis shares her thoughts on the evolving regulatory landscape and what this means for the future of biopharma.
native1_300x100
lorem ipsum